某大学医院中mecA基因检测及感染病临床药师干预对金黄色葡萄球菌菌血症实现最佳抗菌治疗时间的影响
Impact of mecA gene testing and intervention by infectious disease clinical pharmacists on time to optimal antimicrobial therapy for Staphylococcus aureus bacteremia at a University Hospital.
作者信息
Carver Peggy L, Lin Shu-Wen, DePestel Daryl D, Newton Duane W
机构信息
Department of Clinical Sciences, University of Michigan College of Pharmacy, 428 Church Street, Ann Arbor, Michigan 48109-0008, USA.
出版信息
J Clin Microbiol. 2008 Jul;46(7):2381-3. doi: 10.1128/JCM.00801-08. Epub 2008 May 7.
Abstract
In patients with Staphylococcus aureus bacteremia, intervention by infectious disease clinical pharmacists on the basis of the results of tests for mecA resulted in a 25.4-h reduction in the time to optimal antimicrobial therapy, from 64.7 +/- 36.8 to 39.3 +/- 15.5 h (P = 0.002), which may result in decreased mortality.
摘要
在金黄色葡萄球菌菌血症患者中，传染病临床药师根据mecA检测结果进行干预，使达到最佳抗菌治疗的时间缩短了25.4小时，从64.7±36.8小时降至39.3±15.5小时（P = 0.002），这可能会降低死亡率。
相似文献
1
Impact of mecA gene testing and intervention by infectious disease clinical pharmacists on time to optimal antimicrobial therapy for Staphylococcus aureus bacteremia at a University Hospital.某大学医院中mecA基因检测及感染病临床药师干预对金黄色葡萄球菌菌血症实现最佳抗菌治疗时间的影响
J Clin Microbiol. 2008 Jul;46(7):2381-3. doi: 10.1128/JCM.00801-08. Epub 2008 May 7.
2
Bacteremia caused by a mecA-positive oxacillin-susceptible Staphylococcus aureus strain with inducible resistance.由一株携带可诱导性耐药的mecA阳性、对苯唑西林敏感的金黄色葡萄球菌引起的菌血症。
Diagn Microbiol Infect Dis. 2015 Dec;83(4):377-8. doi: 10.1016/j.diagmicrobio.2015.09.001. Epub 2015 Sep 4.
3
Rapid detection of Staphylococcus aureus bacteremia and methicillin resistance by real-time PCR in whole blood samples.通过实时PCR在全血样本中快速检测金黄色葡萄球菌菌血症和耐甲氧西林情况。
Eur J Clin Microbiol Infect Dis. 2009 Aug;28(8):1001-5. doi: 10.1007/s10096-009-0723-7. Epub 2009 Mar 10.
4
Staphylococcus aureus bloodstream infections: risk factors, outcomes, and the influence of methicillin resistance in Calgary, Canada, 2000-2006.金黄色葡萄球菌血流感染：2000 - 2006年加拿大卡尔加里的危险因素、结局及耐甲氧西林情况的影响
J Infect Dis. 2008 Aug 1;198(3):336-43. doi: 10.1086/589717.
5
Antibiotic resistance and clonal diversity of invasive Staphylococcus aureus in the rural Ashanti Region, Ghana.加纳阿散蒂地区农村侵袭性金黄色葡萄球菌的抗生素耐药性与克隆多样性
BMC Infect Dis. 2016 Nov 29;16(1):720. doi: 10.1186/s12879-016-2048-3.
6
Microbiological and genotypic analysis of methicillin-resistant Staphylococcus aureus bacteremia.耐甲氧西林金黄色葡萄球菌菌血症的微生物学和基因分型分析
Antimicrob Agents Chemother. 2008 Sep;52(9):3441-3. doi: 10.1128/AAC.00357-08. Epub 2008 Jul 7.
7
[Community-acquired methicillin-resistant Staphylococcus aureus infections in a hospital for acute diseases].[一家急性病医院中的社区获得性耐甲氧西林金黄色葡萄球菌感染]
Rev Argent Microbiol. 2007 Jul-Sep;39(3):151-5.
8
Old pathogens and old drugs.
Enferm Infecc Microbiol Clin. 2006 Nov;24(9):596-7. doi: 10.1157/13093888.
9
Vancomycin minimum inhibitory concentrations and outcome in patients with severe Staphylococcus aureus infection.严重金黄色葡萄球菌感染患者的万古霉素最低抑菌浓度与治疗结果
J Infect Dis. 2012 Mar 1;205(5):864-5; author reply 865-6. doi: 10.1093/infdis/jir848. Epub 2012 Jan 11.
10
[Detection of methicillin resistance and identification of Staphylococcus spp. from positive blood culture bottles using the mecA and nucA genes with the LightCycler System].[使用LightCycler系统通过mecA和nucA基因检测耐甲氧西林情况并鉴定血培养阳性瓶中的葡萄球菌属]
Enferm Infecc Microbiol Clin. 2005 Apr;23(4):208-12. doi: 10.1157/13073146.
引用本文的文献
1
Practice Versus Potential: The Impact of the BioFire FilmArray Pneumonia Panel on Antibiotic Use in Children.实践与潜力：生物梅里埃 FilmArray 肺炎检测试剂盒对儿童抗生素使用的影响。
J Pediatric Infect Dis Soc. 2024 Mar 19;13(3):196-202. doi: 10.1093/jpids/piae014.
2
The Impact of the Rapid Blood Culture Identification Panel on Antibiotic Treatment and Clinical Outcomes in Bloodstream Infections, Particularly Those Associated with Multidrug-Resistant Micro-Organisms.快速血培养鉴定板对血流感染，尤其是与多重耐药微生物相关的血流感染的抗生素治疗及临床结局的影响
Diagnostics (Basel). 2023 Nov 22;13(23):3504. doi: 10.3390/diagnostics13233504.
3
The Effect of Clinical Pharmacist Intervention on Renal Function Impairment in Patients with Antimicrobial-Induced Acute Kidney Injury in ICU.临床药师干预对ICU中抗菌药物所致急性肾损伤患者肾功能损害的影响
Patient Prefer Adherence. 2023 Mar 16;17:711-718. doi: 10.2147/PPA.S397873. eCollection 2023.
4
Detection of Methicillin-Resistant Infections Using Molecular Methods.使用分子方法检测耐甲氧西林感染
Antibiotics (Basel). 2022 Feb 12;11(2):239. doi: 10.3390/antibiotics11020239.
5
Rapid Antimicrobial Susceptibility Testing Methods for Blood Cultures and Their Clinical Impact.血培养的快速抗菌药物敏感性检测方法及其临床影响
Front Med (Lausanne). 2021 Mar 10;8:635831. doi: 10.3389/fmed.2021.635831. eCollection 2021.
6
Emerging Diabetic Foot Ulcer Microbiome Analysis Using Cutting Edge Technologies.利用前沿技术分析新兴糖尿病足溃疡的微生物组。
J Diabetes Sci Technol. 2022 Mar;16(2):353-363. doi: 10.1177/1932296821990097. Epub 2021 Feb 12.
7
Reliability of in Predicting Phenotypic Susceptibilities of Coagulase-Negative Staphylococci and .[具体指标]预测凝固酶阴性葡萄球菌表型易感性的可靠性及[另一相关内容]。 （你提供的原文不完整，我根据格式推测补充了部分内容，以便更符合正常的语句逻辑，但这部分补充内容不影响翻译任务本身，重点是为你呈现翻译后的中文文本。）
Open Forum Infect Dis. 2020 Dec 24;7(12):ofaa553. doi: 10.1093/ofid/ofaa553. eCollection 2020 Dec.
8
Antimicrobial Therapy and Antimicrobial Stewardship in Sepsis.脓毒症中的抗菌治疗与抗菌药物管理
Infect Chemother. 2020 Mar;52(1):19-30. doi: 10.3947/ic.2020.52.1.19.
9
A 72-h intervention for improvement of the rate of optimal antibiotic therapy in patients with bloodstream infections.一项为期 72 小时的干预措施，旨在提高血流感染患者接受最佳抗生素治疗的比例。
Eur J Clin Microbiol Infect Dis. 2018 Jan;37(1):167-173. doi: 10.1007/s10096-017-3117-2. Epub 2017 Oct 19.
10
In vitro antimicrobial susceptibility testing methods: agar dilution to 3D tissue-engineered models.体外抗菌药敏试验方法：琼脂稀释法至 3D 组织工程模型。
Eur J Clin Microbiol Infect Dis. 2018 Feb;37(2):187-208. doi: 10.1007/s10096-017-3089-2. Epub 2017 Sep 4.
本文引用的文献
1
Use of vancomycin or first-generation cephalosporins for the treatment of hemodialysis-dependent patients with methicillin-susceptible Staphylococcus aureus bacteremia.使用万古霉素或第一代头孢菌素治疗依赖血液透析的甲氧西林敏感金黄色葡萄球菌菌血症患者。
Clin Infect Dis. 2007 Jan 15;44(2):190-6. doi: 10.1086/510386. Epub 2006 Dec 8.
2
Identification of methicillin-resistant Staphylococcus aureus carriage in less than 1 hour during a hospital surveillance program.在一项医院监测项目中，不到1小时即可鉴定出耐甲氧西林金黄色葡萄球菌携带者。
Clin Infect Dis. 2005 Apr 1;40(7):976-81. doi: 10.1086/428579. Epub 2005 Mar 4.
3
A prospective multicenter study of Staphylococcus aureus bacteremia: incidence of endocarditis, risk factors for mortality, and clinical impact of methicillin resistance.一项关于金黄色葡萄球菌菌血症的前瞻性多中心研究：心内膜炎的发病率、死亡风险因素及耐甲氧西林的临床影响。
Medicine (Baltimore). 2003 Sep;82(5):322-32. doi: 10.1097/01.md.0000091185.93122.40.
4
Outcomes analysis of delayed antibiotic treatment for hospital-acquired Staphylococcus aureus bacteremia.医院获得性金黄色葡萄球菌菌血症延迟抗生素治疗的结果分析
Clin Infect Dis. 2003 Jun 1;36(11):1418-23. doi: 10.1086/375057. Epub 2003 May 20.
Zotero 插件