一些新型吡唑啉和吡咯并[3,4-c]吡唑-4,6-二酮衍生物的合成与生物活性：腈亚胺与某些亲偶极体的反应
Synthesis and biological activity of some new pyrazoline and pyrrolo[3,4-c]pyrazole-4,6-dione derivatives: reaction of nitrilimines with some dipolarophiles.
作者信息
Abunada Nada M, Hassaneen Hamdi M, Kandile Nadia G, Miqdad Omar A
机构信息
Department of Chemistry, Faculty of Applied Sciences, Al-Aqsa University, 76888 Gaza, Palestine.
出版信息
Molecules. 2008 Apr 29;13(4):1011-24. doi: 10.3390/molecules13041011.
Several 1,3-diaryl-5-(cyano-, aminocarbonyl- and ethoxycarbonyl-)-2-pyrazoline, pyrrolo[3,4-c]pyrazole-4,6-dione and 1,3,4,5-tetraaryl-2-pyrazoline derivatives were prepared by the reaction of nitrilimine with different dipolarophilic reagents. The new compounds were characterized using IR, (1)H-NMR, (13)C-NMR and mass spectra. Biological screening of some compounds is reported.
通过腈亚胺与不同亲偶极体试剂反应制备了几种1,3-二芳基-5-（氰基-、氨基羰基-和乙氧羰基-）-2-吡唑啉、吡咯并[3,4-c]吡唑-4,6-二酮和1,3,4,5-四芳基-2-吡唑啉衍生物。利用红外光谱、¹H-核磁共振、¹³C-核磁共振和质谱对新化合物进行了表征。报道了对一些化合物的生物活性筛选。
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