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一些新型吡唑啉和吡咯并[3,4-c]吡唑-4,6-二酮衍生物的合成与生物活性：腈亚胺与某些亲偶极体的反应

Synthesis and biological activity of some new pyrazoline and pyrrolo[3,4-c]pyrazole-4,6-dione derivatives: reaction of nitrilimines with some dipolarophiles.

作者信息

Abunada Nada M, Hassaneen Hamdi M, Kandile Nadia G, Miqdad Omar A

机构信息

Department of Chemistry, Faculty of Applied Sciences, Al-Aqsa University, 76888 Gaza, Palestine.

出版信息

Molecules. 2008 Apr 29;13(4):1011-24. doi: 10.3390/molecules13041011.

DOI:10.3390/molecules13041011
PMID:18463603
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC6245437/
Abstract

Several 1,3-diaryl-5-(cyano-, aminocarbonyl- and ethoxycarbonyl-)-2-pyrazoline, pyrrolo[3,4-c]pyrazole-4,6-dione and 1,3,4,5-tetraaryl-2-pyrazoline derivatives were prepared by the reaction of nitrilimine with different dipolarophilic reagents. The new compounds were characterized using IR, (1)H-NMR, (13)C-NMR and mass spectra. Biological screening of some compounds is reported.

摘要

通过腈亚胺与不同亲偶极体试剂反应制备了几种1,3-二芳基-5-（氰基-、氨基羰基-和乙氧羰基-）-2-吡唑啉、吡咯并[3,4-c]吡唑-4,6-二酮和1,3,4,5-四芳基-2-吡唑啉衍生物。利用红外光谱、¹H-核磁共振、¹³C-核磁共振和质谱对新化合物进行了表征。报道了对一些化合物的生物活性筛选。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/0062/6245437/d277c93f9344/molecules-13-01011-g001.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/0062/6245437/d277c93f9344/molecules-13-01011-g001.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/0062/6245437/d277c93f9344/molecules-13-01011-g001.jpg

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本文引用的文献

1
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Bioorg Med Chem Lett. 2008 Feb 1;18(3):918-22. doi: 10.1016/j.bmcl.2007.12.043. Epub 2008 Jan 7.
2
Synthesis and studies on antidepressant and anticonvulsant activities of some 3-(2-furyl)-pyrazoline derivatives.某些3-(2-呋喃基)-吡唑啉衍生物的合成及其抗抑郁和抗惊厥活性研究
Eur J Med Chem. 2007 Mar;42(3):373-9. doi: 10.1016/j.ejmech.2006.09.006. Epub 2006 Oct 25.
3
Synthesis, structural activity relationship and anti-tubercular activity of novel pyrazoline derivatives.
合成、表征及新型 WNT/β-catenin 信号通路抑制剂的评价。
Mol Cancer. 2013 Oct 7;12(1):116. doi: 10.1186/1476-4598-12-116.
4
Recent advances in the therapeutic applications of pyrazolines.吡唑啉类治疗应用的最新进展。
Expert Opin Ther Pat. 2012 Mar;22(3):253-91. doi: 10.1517/13543776.2012.667403. Epub 2012 Mar 8.
5
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Molecules. 2008 Jul 29;13(7):1501-17. doi: 10.3390/molecules13071501.
新型吡唑啉衍生物的合成、构效关系及抗结核活性
Eur J Med Chem. 2007 Feb;42(2):268-75. doi: 10.1016/j.ejmech.2006.08.004. Epub 2006 Sep 26.
4
Synthesis and antidepressant activity of some 1,3,5-triphenyl-2-pyrazolines and 3-(2''-hydroxy naphthalen-1''-yl)-1,5-diphenyl-2-pyrazolines.某些1,3,5-三苯基-2-吡唑啉和3-(2''-羟基萘-1''-基)-1,5-二苯基-2-吡唑啉的合成及抗抑郁活性
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5
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Arzneimittelforschung. 2005;55(8):431-6.
6
Synthesis and antidepressant activities of some 3,5-diphenyl-2-pyrazolines.某些3,5-二苯基-2-吡唑啉的合成与抗抑郁活性
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7
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8
Antibacterials and antimycotics: Part 1: Synthesis and activity of 2-pyrazoline derivatives.
Chem Pharm Bull (Tokyo). 1998 Aug;46(8):1254-60. doi: 10.1248/cpb.46.1254.
9
Structure-activity relationships of antibacterial 6,7- and 7,8-disubstituted 1-alkyl-1,4-dihydro-4-oxoquinoline-3-carboxylic acids.抗菌性6,7 - 及7,8 - 二取代1 - 烷基 - 1,4 - 二氢 - 4 - 氧代喹啉 - 3 - 羧酸的构效关系
J Med Chem. 1980 Dec;23(12):1358-63. doi: 10.1021/jm00186a014.
10
Synthesis and antibacterial activities of substituted 7-oxo-2,3-dihydro-7H-pyrido[1,2,3-de][1,4]benzoxazine-6-carboxyl ic acids.取代的7-氧代-2,3-二氢-7H-吡啶并[1,2,3-德][1,4]苯并恶嗪-6-羧酸的合成与抗菌活性
Chem Pharm Bull (Tokyo). 1984 Dec;32(12):4907-13. doi: 10.1248/cpb.32.4907.