PG & Research Department of Chemistry, Government Arts College, C-Mutlur 608102, Chidambaram, India.
Spectrochim Acta A Mol Biomol Spectrosc. 2012 Sep;95:693-700. doi: 10.1016/j.saa.2012.04.082. Epub 2012 Apr 25.
A series of 2-naphthyl pyrazolines were synthesized by the cyclization of 2-naphthyl chalcones and phenylhydrazine hydrochloride in the presence of sodium acetate. The yields of pyrazoline derivatives are more than 80%. The synthesized pyrazolines were characterized by their physical constants, IR, (1)H, (13)C and MS spectra. From the IR and NMR spectra the C=N (cm(-1)) stretches, the pyrazoline ring proton chemical shifts (ppm) of δ(Ha), H(b) and H(c) and also the carbon chemical shifts (ppm) of δC=N are correlated with Hammett substituent constants, F and R, and Swain-Lupton's parameters using single and multi-regression analyses. From the results of linear regression analysis, the effect of substituents on the group frequencies has been predicted. The antimicrobial activities of all synthesized pyrazolines have been studied.
一系列 2-萘基吡唑啉类化合物是通过 2-萘基查耳酮和苯肼盐酸盐在醋酸钠存在下环化合成的。吡唑啉衍生物的产率超过 80%。合成的吡唑啉类化合物通过其物理常数、IR、（1）H、（13）C 和 MS 光谱进行表征。从 IR 和 NMR 光谱中，C=N（cm（-1））伸缩，吡唑啉环质子化学位移（ppm）δ（Ha）、H（b）和 H（c）以及碳化学位移（ppm）δC=N 与哈米特取代常数 F 和 R 以及斯温和卢普顿的参数相关联使用单回归和多回归分析。从线性回归分析的结果可以预测取代基对基团频率的影响。所有合成的吡唑啉类化合物的抗菌活性都进行了研究。
