从云南鼠尾草中分离出的三种新型抗HIV-1多酚衍生物。
Three new derivatives of anti-HIV-1 polyphenols isolated from Salvia yunnanensis.
作者信息
Zhang Zheng-Fu, Peng Zong-Gen, Gao Lei, Dong Biao, Li Jian-Rui, Li Zhuo-Yong, Chen Hong-Shan
机构信息
Chinese Academy of Medical Sciences, Institute of Medicinal Biotechnology, Beijing, China.
出版信息
J Asian Nat Prod Res. 2008 May-Jun;10(5-6):391-6. doi: 10.1080/10286020801966591.
During the study of anti-HIV-1 active components of the aqueous extracts of the roots of Salvia yunnanensis, three new derivatives of polyphenols, namely: methyl salvianolate A (2), ethyl salvianolate A (3) and cis-lithospermic acid (5) were isolated along with two known polyphenols, salvianolic acid A (1) and lithospermic acid (4) their structures were elucidated on the basis of NMR and MS spectral analyses. The anti-HIV-1 activities of the 5 polyphenols were tested for the inhibition of P24 antigen in HIV-1 infected MT-4 cell cultures and HIV-1 replicative enzymes in vitro.
在对云南鼠尾草根部水提取物的抗HIV-1活性成分进行研究期间，分离得到了三种新的多酚衍生物，即：丹酚酸A甲酯（2）、丹酚酸A乙酯（3）和顺式紫草酸（5），同时还得到了两种已知的多酚，丹酚酸A（1）和紫草酸（4），并通过核磁共振（NMR）和质谱（MS）光谱分析确定了它们的结构。对这5种多酚的抗HIV-1活性进行了测试，以检测其对HIV-1感染的MT-4细胞培养物中P24抗原的抑制作用以及对HIV-1复制酶的体外抑制作用。
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