University of Novi Sad, Faculty of Medicine, Department of Pharmacy, Hajduk Veljkova 3, 21000 Novi Sad, Serbia.
University of Novi Sad, Faculty of Medicine, Department of Infectious Diseases, Hajduk Veljkova 3, 21000 Novi Sad, Serbia; Clinical Centre of Vojvodina, Clinic for Infectious Diseases, Hajduk Veljkova 1, 21000 Novi Sad, Serbia.
Pharmacol Res. 2018 Jul;133:301-314. doi: 10.1016/j.phrs.2017.12.016. Epub 2017 Dec 16.
Constant search for new drugs with antiviral properties often extends to products of natural origin. Lamiaceae is one of the most important herbal families, well known for various biological and medicinal effects of a variety of aromatic spices, including thyme, mint, oregano, basil, sage, savory, rosemary, self-heal, hyssop, lemon balm and many others. The paper provides a review of antiviral potential of previously mentioned plants which has been demonstrated so far, with special emphasis on anti-HIV properties. Relevant articles were compiled by searching plant names combined with keywords describing antiviral activity. The antiviral effect is direct, with prominent activity against enveloped viral species. Initial stages of the viral life cycle are the most affected, as these plants appear to be targeting mainly viral structures responsible for attachment to target cells. In case of HIV, there is some activity against key enzymes in the viral life cycle. Even in the case of drug resistance, there is an equal susceptibility to applied herbal preparations. Some in vivo experiments suggest that use of Lamiaceae representatives could help in prevention and treatment of some viral diseases. A possible reduction of side effects of diseases and conventional drug therapy are also some aspects worth further investigations.
人们一直在不断寻找具有抗病毒特性的新药，而这些新药往往来源于天然产物。唇形科是最重要的草药家族之一，以各种芳香香料（包括百里香、薄荷、牛至、罗勒、鼠尾草、马郁兰、迷迭香、接骨木、海索草、藿香和柠檬香脂等）的多种生物和药用功效而闻名。本文综述了迄今为止已证实的上述植物的抗病毒潜力，特别强调了它们的抗 HIV 特性。通过搜索植物名称并结合描述抗病毒活性的关键词来编译相关文章。这些植物的抗病毒作用是直接的，对包膜病毒具有明显的活性。病毒生命周期的早期阶段受影响最大，因为这些植物似乎主要针对负责与靶细胞附着的病毒结构。在 HIV 的情况下，针对病毒生命周期中的关键酶也有一些活性。即使是在耐药的情况下，应用草药制剂也同样容易被抑制。一些体内实验表明，使用唇形科植物可能有助于预防和治疗某些病毒性疾病。减少疾病和常规药物治疗的副作用也是值得进一步研究的一些方面。
