Li Xinjun, Sundquist Jan, Sundquist Kristina
Center for Family and Community Medicine, Karolinska Institute, Huddinge, Sweden.
J Rheumatol. 2008 Jun;35(6):986-91. Epub 2008 May 1.
To investigate possible associations between socioeconomic status, occupation, and hospitalization for rheumatoid arthritis (RA).
A nationwide database was constructed by linking the Swedish Census to the Hospital Discharge Register in order to obtain data on all first hospitalizations for RA in Sweden during the study period 1964 to 2004. Standardized incidence ratios (SIR) and 95% confidence intervals were calculated by socioeconomic status (education level) and occupation for men and women aged 30 years and older. Three cohorts were defined based on occupational titles recorded in Swedish census data in 1960, 1970, and 1980.
A total of 13,820 male and 14,509 female hospitalizations for RA were identified during the study period. Men and women with an education level > 12 years had significantly decreased SIR. Among men, significantly increased SIR were present in all 3 cohorts among farmers, miners and quarry workers, electrical workers, other construction workers, and engine and motor operators. Among women, assistant nurses and religious, juridical, and other social-science-related workers had significantly increased SIR in all 3 cohorts.
Socioeconomic status and occupation sometimes carry a significantly increased risk of hospitalization for RA. Future studies could investigate specific agents in the occupations for which increased risks are identified.
探讨社会经济地位、职业与类风湿关节炎（RA）住院治疗之间的可能关联。
通过将瑞典人口普查数据与医院出院登记数据相链接，构建了一个全国性数据库，以获取1964年至2004年研究期间瑞典所有首次因RA住院的患者数据。按社会经济地位（教育水平）和职业，计算了30岁及以上男性和女性的标准化发病率（SIR）及95%置信区间。根据1960年、1970年和1980年瑞典人口普查数据中记录的职业头衔定义了三个队列。
研究期间共确定了13820例男性和14509例女性因RA住院。教育水平超过12年的男性和女性的SIR显著降低。在男性中，农民、矿工和采石工人、电工、其他建筑工人以及发动机和电机操作员这三个队列中的SIR均显著升高。在女性中，助理护士以及宗教、司法和其他社会科学相关工作者在这三个队列中的SIR均显著升高。
社会经济地位和职业有时会使RA住院风险显著增加。未来的研究可以调查已确定风险增加的职业中的特定因素。
