Li Xinjun, Sundquist Kristina, Sundquist Jan
Center for Primary Health Care Research, Lund University, Scania, Sweden.
J Asthma. 2009 Oct;46(8):815-21.
Our aim was to analyze risk of first hospital diagnosis of asthma in children (< 10 years) and adolescents (10 through 19 years) in Sweden between 1970 and 2004 by parental occupation, controlling for potential confounders. Data from the Multigeneration Register, in which all children born in Sweden from 1932 onward are registered with their parents, were linked to nationwide Hospital Register data. Standardized incidence ratios (SIRs) with 95% confidence intervals were calculated. A total of 47,019 first hospital diagnoses of asthma were recorded in children and 9,032 in adolescents. After accounting for age at diagnosis, sex, socioeconomic status, geographic region, parental history of a first hospital diagnosis of asthma, and period of diagnosis, 17 parental occupational groups were associated with increased risk of first hospital diagnosis of asthma in children and 9 with increased risk in adolescents. Seven parental occupational groups were associated with significantly increased risks in both children and adolescents: "nurses," "assistant nurses," "drivers," "chemical process workers," "cooks and stewards," "home helpers," and "building caretakers and cleaners." Significantly decreased SIRs were observed for those whose parents had higher socioeconomic status. We conclude that parental occupation affects risk of first hospital diagnoses of asthma in children and adolescents.
我们的目的是通过父母职业分析1970年至2004年间瑞典10岁以下儿童和10至19岁青少年首次因哮喘住院诊断的风险，并控制潜在的混杂因素。多代登记册记录了1932年起在瑞典出生的所有儿童及其父母的信息，该登记册数据与全国医院登记数据相关联。计算了标准化发病率（SIR）及95%置信区间。儿童中共有47,019例首次因哮喘住院诊断记录，青少年中有9,032例。在考虑诊断时的年龄、性别、社会经济地位、地理区域、父母首次因哮喘住院诊断的病史以及诊断时期后，17个父母职业组与儿童首次因哮喘住院诊断的风险增加相关，9个与青少年风险增加相关。七个父母职业组与儿童和青少年的风险均显著增加相关：“护士”、“助理护士”、“司机”、“化学工艺工人”、“厨师和乘务员”、“家庭帮佣”以及“大楼管理员和清洁工”。父母社会经济地位较高者的标准化发病率显著降低。我们得出结论，父母职业会影响儿童和青少年首次因哮喘住院诊断的风险。
