从一株栖藻黄曲霉中分离得到的一种新型二酮哌嗪生物碱。
A new diketopiperazine alkaloid isolated from an algicolous Aspergillus flavus strain.
作者信息
Lin Aiqun, Fang Yuchun, Zhu Tianjiao, Gu Qianqun, Zhu Weiming
机构信息
Key Laboratory of Marine Drugs, Chinese Ministry of Education, Institute of Marine Drugs and Food, Ocean University of China, Qingdao, People's Republic of China.
出版信息
Pharmazie. 2008 Apr;63(4):323-5.
A new diketopiperazine alkaloid containing the uncommon amino acid L-7, 9-dihydroxy-8-methoxyphenylalanine (1), has been isolated from the algicolous Aspergillus flavus strain. The structure of 1 including the absolute stereochemistry was determined by spectroscopic data and chemical means. Compound 1 showed weak cytotoxicity against HL-60 cell lines with an IC50 value of 36.5 microg/ml.
从寄生曲霉黄曲霉菌株中分离出一种新的含有罕见氨基酸L-7, 9-二羟基-8-甲氧基苯丙氨酸的二酮哌嗪生物碱(1)。通过光谱数据和化学方法确定了1的结构，包括绝对立体化学。化合物1对HL-60细胞系显示出较弱的细胞毒性，IC50值为36.5微克/毫升。
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