植物内生真菌 Aspergillus terreus 中的生物活性生物碱。

Bioactive alkaloids from the plant endophytic fungus Aspergillus terreus.

机构信息

Institute of Functional Biomolecules, State Key Laboratory of Pharmaceutical Biotechnology, School of Lifesciences, Nanjing University, Nanjing, PR China.

出版信息

Planta Med. 2010 May;76(8):822-4. doi: 10.1055/s-0029-1240726. Epub 2010 Jan 11.

DOI:10.1055/s-0029-1240726

PMID:20066611

Abstract

One new alkaloid, named 16 alpha-hydroxy-5 N-acetylardeemin ( 1), along with seven known metabolites ( 2- 8) was isolated from the fermentation broth of an endophytic fungus, ASPERGILLUS TERREUS. The structures of these metabolites were assigned on the basis of detailed spectroscopic analysis and by comparing spectroscopic data with those in the literature. Compound 1 displayed an inhibitory effect against acetylcholinesterase. Compounds 1- 8 also showed moderate or weak cytotoxic activity against KB and HSC-T6 cell lines.

摘要

从一株内生真菌 ASPERGILLUS TERREUS 的发酵液中分离得到一个新的生物碱，命名为 16α-羟基-5N-乙酰阿替麦考林（1），以及七个已知代谢产物（2-8）。这些代谢产物的结构是根据详细的光谱分析和与文献中的光谱数据比较来确定的。化合物 1 对乙酰胆碱酯酶表现出抑制作用。化合物 1-8 对 KB 和 HSC-T6 细胞系也表现出中等或较弱的细胞毒性。