从海洋来源真菌黄曲霉中分离出的两种新的5-羟基-2-吡喃酮衍生物。

Two new 5-hydroxy-2-pyrone derivatives isolated from a marine-derived fungus Aspergillus flavus.

作者信息

Lin Aiqun, Lu Xiaoming, Fang Yuchun, Zhu Tianjiao, Gu Qianqun, Zhu Weiming

机构信息

Key Laboratory of Marine Drugs, Chinese Ministry of Education, School of Medicine and Pharmacy, Ocean University of China.

出版信息

J Antibiot (Tokyo). 2008 Apr;61(4):245-9. doi: 10.1038/ja.2008.36.

DOI:10.1038/ja.2008.36

PMID:18503205

Abstract

Two new compounds, 4-(hydroxymethyl)-5-hydroxy-2H-pyran-2-one (1) and (5-hydroxy-2-oxo-2H-pyran-4-yl) methyl acetate (2), have been isolated from a marine-derived fungus Aspergillus flavus. Their structures were determined by spectroscopic data. Compound 1 induced the production of cAMP on GPR12 transfected CHO and HEK293 cells in a dose-dependent manner, which indicated 1 might be a possible ligand for GPR12.

摘要

从海洋来源的黄曲霉中分离出了两种新化合物，4-(羟甲基)-5-羟基-2H-吡喃-2-酮(1)和(5-羟基-2-氧代-2H-吡喃-4-基)甲基乙酸酯(2)。它们的结构通过光谱数据确定。化合物1在转染了GPR12的CHO和HEK293细胞上以剂量依赖性方式诱导cAMP的产生，这表明化合物1可能是GPR12的潜在配体。