Lin Aiqun, Lu Xiaoming, Fang Yuchun, Zhu Tianjiao, Gu Qianqun, Zhu Weiming
Key Laboratory of Marine Drugs, Chinese Ministry of Education, School of Medicine and Pharmacy, Ocean University of China.
J Antibiot (Tokyo). 2008 Apr;61(4):245-9. doi: 10.1038/ja.2008.36.
Two new compounds, 4-(hydroxymethyl)-5-hydroxy-2H-pyran-2-one (1) and (5-hydroxy-2-oxo-2H-pyran-4-yl) methyl acetate (2), have been isolated from a marine-derived fungus Aspergillus flavus. Their structures were determined by spectroscopic data. Compound 1 induced the production of cAMP on GPR12 transfected CHO and HEK293 cells in a dose-dependent manner, which indicated 1 might be a possible ligand for GPR12.
从海洋来源的黄曲霉中分离出了两种新化合物，4-(羟甲基)-5-羟基-2H-吡喃-2-酮(1)和(5-羟基-2-氧代-2H-吡喃-4-基)甲基乙酸酯(2)。它们的结构通过光谱数据确定。化合物1在转染了GPR12的CHO和HEK293细胞上以剂量依赖性方式诱导cAMP的产生，这表明化合物1可能是GPR12的潜在配体。
