Brunkhorst R, Eberhardt O K, Haubitz M, Brunkhorst F M
Medizinische Hochschule Hannover, Abt. Nephrologie, Carl-Neubert-Str.1, D-30623 Hannover, Germany.
Intensive Care Med. 2000 Mar;26 Suppl 2:S199-201. doi: 10.1007/BF02900738.
To investigate whether serum procalcitonin (PCT) levels could be useful to differentiate between systemic infection and the activity of the underlying disease in autoimmune disease.
In 18 patients with systemic lupus erythematodes (SLE) and 35 patients with systemic antineutrophil cytoplasmic antibody-associated vasculitis (AAV) clinical disease activity was assessed by score systems. Infection was defined by clinical and microbiological means. PCT was determined in parallel with concentrations of neopterin, interleukin-6 (IL-6), and C-reactive protein (CRP) in 397 serum samples.
Only in 3 of the 324 samples taken from patients with autoimmune disease but without concomitant infection, serum PCT levels were above the normal range (>0.5 ng/ml), whereas neopterin, CRP and IL-6 were elevated in patients with active underlying disease. All systemic infections (N=16 in AAV-patients) were associated with markedly elevated PCT-levels (mean+/-SD:1.93+/-1.19 ng/ml).
PCT may serve as a useful marker for the detection of systemic bacterial infection in patients with autoimmune disease.
探讨血清降钙素原（PCT）水平是否有助于区分自身免疫性疾病中的全身感染与基础疾病的活动情况。
采用评分系统评估18例系统性红斑狼疮（SLE）患者和35例系统性抗中性粒细胞胞浆抗体相关性血管炎（AAV）患者的临床疾病活动度。通过临床和微生物学方法定义感染。在397份血清样本中，同时测定PCT以及蝶呤、白细胞介素-6（IL-6）和C反应蛋白（CRP）的浓度。
在324份取自无合并感染的自身免疫性疾病患者的样本中，仅3份血清PCT水平高于正常范围（>0.5 ng/ml），而基础疾病活动的患者中蝶呤、CRP和IL-6升高。所有全身感染（AAV患者中16例）均伴有PCT水平显著升高（均值±标准差：1.93±1.19 ng/ml）。
PCT可作为检测自身免疫性疾病患者全身细菌感染的有用标志物。
