Richard M, Vignon E, Peschard M J, Broquet P, Carret J P, Louisot P
Department of General and Medical Biochemistry, INSERM-CNRS U 189 Lyon-Sud Medical School, Oullins, France.
FEBS Lett. 1991 Jan 14;278(1):38-40. doi: 10.1016/0014-5793(91)80078-h.
We have previously described several receptors on the chondrocyte membrane. In an attempt to further characterize the coupling mechanisms of serotoninergic receptors, here we examined the involvement of serotonin in the phospholipase A2 activity. Serotonin dose-dependently stimulated phospholipase A2. This activation enhanced collagenase type II activity and had no effect on proteoglycanase activity.
我们之前已经描述过软骨细胞膜上的几种受体。为了进一步表征血清素能受体的偶联机制，我们在此研究了血清素在磷脂酶A2活性中的作用。血清素以剂量依赖的方式刺激磷脂酶A2。这种激活增强了II型胶原酶的活性，而对蛋白聚糖酶的活性没有影响。
