Xu Xiuling, Chen Xuesi, Ma Ping'an, Wang Xinri, Jing Xiabin
State Key Laboratory of Polymer Physics and Chemistry, Changchun Institute of Applied Chemistry, Changchun, China.
Eur J Pharm Biopharm. 2008 Sep;70(1):165-70. doi: 10.1016/j.ejpb.2008.03.010. Epub 2008 Mar 28.
The release behavior of a water-soluble small molecule drug from the drug-loaded nanofibers prepared by emulsion-electrospinning was investigated. Doxorubicin hydrochloride (Dox), a water-soluble anticancer agent, was used as the model drug. The laser scanning confocal microscopic images indicated that the drug was well incorporated into amphiphilic poly(ethylene glycol)-poly(L-lactic acid) (PEG-PLA) diblock copolymer nanofibers, forming "core-sheath" structured drug-loaded nanofibers. The drug release behavior of this drug-loaded system showed a three-stage diffusion-controlled mechanism, in which the release rate of the first stage was slower than that of the second stage, but both obeyed Fick's second law. Based on these results, it is concluded that the Dox-loaded fibers prepared by emulsion-electrospinning represent a reservoir-type delivery system in which the Dox release rate decreases with the increasing Dox content in the fibers.
研究了通过乳液静电纺丝制备的载药纳米纤维中水溶性小分子药物的释放行为。使用水溶性抗癌剂盐酸多柔比星（Dox）作为模型药物。激光扫描共聚焦显微镜图像表明，药物很好地掺入两亲性聚（乙二醇）-聚（L-乳酸）（PEG-PLA）二嵌段共聚物纳米纤维中，形成“核-壳”结构的载药纳米纤维。该载药体系的药物释放行为呈现出三阶段扩散控制机制，其中第一阶段的释放速率比第二阶段慢，但两者均符合菲克第二定律。基于这些结果，得出结论：通过乳液静电纺丝制备的载Dox纤维代表一种储库型递送系统，其中Dox的释放速率随着纤维中Dox含量的增加而降低。
