Najjar T A, Lerdrit W, Parsons J R
University of Medicine and Dentistry of New Jersey.
Oral Surg Oral Med Oral Pathol. 1991 Jan;71(1):9-15. doi: 10.1016/0030-4220(91)90512-b.
This study was undertaken to determine whether the addition of calcium sulfate to hydroxylapatite (HA) implant material would improve its working properties without adversely affecting its osseointegration. The clinical and histologic examinations of bone response of three implant materials, hard tissue replacement (HTR), HA, and HA composite (HA plus calcium sulfate), were performed after 2-, 4-, and 6-week implantation in tibia and mandible of rabbits. No sign of extensive chronic inflammatory response was detected. The highest rate of bone ingrowth occurred with the HA composite, followed by HA, with HTR showing the least ingrowth. Bone was deposited directly on the surface of HA and HA composite implant materials. In contrast, HTR particles had a thin layer of fibrous tissue encapsulation with the normal bony investment.
本研究旨在确定向羟基磷灰石（HA）植入材料中添加硫酸钙是否会改善其工作性能，而不会对其骨整合产生不利影响。在将三种植入材料，即硬组织替代物（HTR）、HA和HA复合材料（HA加硫酸钙）植入兔胫骨和下颌骨2周、4周和6周后，对其骨反应进行了临床和组织学检查。未检测到广泛慢性炎症反应的迹象。HA复合材料的骨长入率最高，其次是HA，HTR的骨长入最少。骨直接沉积在HA和HA复合材料植入材料的表面。相比之下，HTR颗粒有一层薄薄的纤维组织包裹，周围是正常的骨组织。
