Donohue W B, Mascrès C
Division of Oral Pathology, Faculty of Dental Medicine, Université de Montréal, Canada.
Int J Oral Maxillofac Implants. 1993;8(1):75-82.
The bone response to two hydroxyapatite (HA) products (Osteogen and Alveograf) and a porous methacrylate resin material (HTR) in rats was compared. Fifty rats had four holes drilled in each iliac crest. The three alloplasts were placed in separate cavities and the fourth cavity was left empty as an absolute control. The survival times varied. The results were evaluated by subjective and histomorphometric analysis. Data were analyzed with ANOVA. There was a statistical difference in bone apposition between HTR and the HA products. The HTR was less osteoconductive, while HA consistently showed dense bone formation. The HA products are generally associated with greater bone formation, suggesting that HA is a better material for bone replacement than HTR.
比较了大鼠对两种羟基磷灰石（HA）产品（Osteogen和Alveograf）以及一种多孔甲基丙烯酸树脂材料（HTR）的骨反应。50只大鼠的每侧髂嵴钻四个孔。将三种异体植入物分别置于不同的腔隙中，第四个腔隙留空作为绝对对照。存活时间各不相同。通过主观和组织形态计量学分析对结果进行评估。数据采用方差分析。HTR与HA产品之间在骨附着方面存在统计学差异。HTR的骨传导性较差，而HA始终显示出致密的骨形成。HA产品通常与更多的骨形成相关，这表明HA是比HTR更好的骨替代材料。
