体内单核吞噬细胞迁移：肾上腺切除术的矛盾效应。
In vivo Mononuclear Phagocyte Migration: Paradoxical Effect of Adrenalectomy.
机构信息
Department of Pharmacology Faculty of Medicine (Ribeirão Preto) USP Av. Bandeirantes 3900 Ribeirão Preto SP 14049-000 Brazil.
出版信息
Mediators Inflamm. 1994;3(4):275-9. doi: 10.1155/S0962935194000372.
The effect of adrenalectomy on neutrophil and monocyte migration into rat peritoneal and pleural cavities was investigated. Carrageenin- or thioglycollate-induced neutrophil emigration into both cavities was enhanced by adrenalectomy. In contrast, monocyte migration into peritoneal cavities induced by these two stimuli was significantl decreased. In pleural cavities, adrenalectomy enhanced the monocyte migration induced by carrageenin but had no effect on that induced by thioglycollate. Administration of physiological doses of glucocorticoids reversed the effect of adrenalectomy on monocyte migration by both stimuli into both cavities. The results support the hypothesis that endogenous glucocorticotds negatively control neutrophil migration independently of the site or type of stimulus. Their role in monocyte migration is, however, dependent on the site of injury and on the type of inflammatory stimulus. There is no obvious explanation for the divergent influence of endogenous glucocorticoids on the monocyte emigration into peritoneal and pleural cavities observed with different stimuli.
研究了肾上腺切除术对大鼠腹膜和胸腔中性粒细胞和单核细胞迁移的影响。角叉菜胶或巯基醋酸盐诱导的中性粒细胞向这两个腔室的迁移均被肾上腺切除术增强。相比之下，两种刺激物诱导的单核细胞向腹膜腔的迁移显著降低。在胸腔中，肾上腺切除术增强了角叉菜胶诱导的单核细胞迁移，但对巯基醋酸盐诱导的单核细胞迁移没有影响。给予生理剂量的糖皮质激素可逆转肾上腺切除术对两种刺激物诱导的中性粒细胞和单核细胞向两个腔室迁移的影响。这些结果支持了这样一种假说，即内源性糖皮质激素独立于刺激的部位或类型负向控制中性粒细胞迁移。然而，它们在单核细胞迁移中的作用取决于损伤部位和炎症刺激的类型。对于不同刺激物观察到的内源性糖皮质激素对单核细胞向腹膜和胸腔迁移的不同影响，目前还没有明显的解释。
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