Cunha F Q, Heluy-Neto N E, Klein A, Souza G E, Ferreira S H
Department of Pharmacology, Faculty of Medicine, University of São Paulo, Ribeirão Preto, Brazil.
Agents Actions. 1988 Aug;25(1-2):191-4. doi: 10.1007/BF01969111.
The ability of PAF-acether (platelet activating factor, 1-alkyl-2-acetyl-sn-glycero-3-phosphocholine) to induce neutrophil migration was tested in the peritoneal cavities of rats and guinea-pigs and in rat skin air pouches. PAF-acether, at doses of 2 and 5 micrograms per animal, did not promote significant neutrophil migration. The ability of PAF-acether antagonists to inhibit carrageenin induced neutrophil migration in rat abdominal cavities was also investigated. Carrageenin is a substance described to cause the release of endogenous PAF-acether. Neutrophil migration was not affected by PAF-antagonists. These observations challenge the possible role of PAF-acether as a neutrophil chemotactic factor in vivo.
在大鼠和豚鼠的腹腔以及大鼠皮肤气囊中测试了血小板活化因子（PAF-乙醚，1-烷基-2-乙酰基-sn-甘油-3-磷酸胆碱）诱导中性粒细胞迁移的能力。每只动物给予2微克和5微克剂量的PAF-乙醚，并未促进明显的中性粒细胞迁移。还研究了PAF-乙醚拮抗剂抑制角叉菜胶诱导的大鼠腹腔中性粒细胞迁移的能力。角叉菜胶是一种被描述为可引起内源性PAF-乙醚释放的物质。中性粒细胞迁移不受PAF拮抗剂的影响。这些观察结果对PAF-乙醚在体内作为中性粒细胞趋化因子的可能作用提出了质疑。
