Joyce Sebastian, Van Kaer Luc
Department of Microbiology and Immunology, Vanderbilt University School of Medicine, Nashville, TN 37232, USA.
Cell Host Microbe. 2008 May 15;3(5):275-7. doi: 10.1016/j.chom.2008.04.007.
How innate immune response causes autoimmunity has remained an enigma. In this issue of Cell Host & Microbe, Mattner et al. demonstrate that invariant natural killer T cells activated by the mucosal commensal Novosphingobium aromaticivorans precipitate chronic T cell-mediated autoimmunity against small bile ducts that mirrors human primary biliary cirrhosis. These findings provide a mechanistic understanding of the role of innate immunity toward a microbe in the development of autoimmunity.
固有免疫反应如何引发自身免疫一直是个谜。在本期《细胞宿主与微生物》中，马特纳等人证明，被黏膜共生菌芳香新鞘氨醇杆菌激活的不变自然杀伤T细胞会引发针对小胆管的慢性T细胞介导的自身免疫，这与人类原发性胆汁性肝硬化相似。这些发现为固有免疫针对微生物在自身免疫发展中的作用提供了机制上的理解。
