Lavanya Raghavan, Wong Tien-Yin, Friedman David S, Aung Han T, Alfred Tamuno, Gao Hong, Seah Steve K, Kashiwagi Kenji, Foster Paul J, Aung Tin
Department of Glaucoma, Singapore National Eye Center and Eye Research Institute, 11 Third Hospital Ave, Singapore 168751.
Arch Ophthalmol. 2008 May;126(5):686-91. doi: 10.1001/archopht.126.5.686.
To investigate systemic and ocular risk factors for angle closure (AC) in older Singaporeans and to determine if these risk factors are different in men vs women and in Chinese vs non-Chinese persons.
A cross-sectional study of 2042 subjects with phakia 50 years or older recruited from a primary care clinic in Singapore. Subjects completed a detailed questionnaire and underwent refraction, biometry, and gonioscopy. Univariate and multivariate analyses were performed to determine risk factors for AC.
The prevalence of AC among this study population was 19.3% (n = 395); 89.4% (n = 1826) of the study population were Chinese. In univariate analysis, patients with AC were older, female, and of Chinese descent and had shorter axial length, lower body mass index, higher intraocular pressure, and shallower anterior chamber depth. In multivariate analysis, female sex (odds ratio [OR], 1.43; 95% confidence interval [CI], 1.06-1.92; P =.02), Chinese race/ethnicity (OR, 3.58; 95% CI, 2.03-6.29; P < .001), axial length (OR per millimeter increase, 0.69; 95% CI, 0.58-0.81; P<.001), and central anterior chamber depth of less than 2.80 mm vs at least 3.00 mm (OR, 42.5; 95% CI, 27.4-66.2; P<.001) were independently associated with AC.
In this community-based study of older Singaporeans, statistically significant independent predictors of AC were female sex, shorter axial length, shallower central anterior chamber depth, and Chinese race/ethnicity. Sex and racial/ethnic differences in the risk of AC were not fully explained by sex and racial/ethnic variations in axial length or anterior chamber depth.
调查新加坡老年人闭角型青光眼（AC）的全身及眼部危险因素，并确定这些危险因素在男性与女性、华裔与非华裔人群中是否存在差异。
一项横断面研究，从新加坡一家初级保健诊所招募了2042名年龄在50岁及以上的有晶状体眼受试者。受试者完成一份详细问卷，并接受验光、生物测量和前房角镜检查。进行单因素和多因素分析以确定AC的危险因素。
该研究人群中AC的患病率为19.3%（n = 395）；研究人群中89.4%（n = 1826）为华裔。单因素分析显示，AC患者年龄更大、为女性、华裔，眼轴较短、体重指数较低、眼压较高、前房深度较浅。多因素分析显示，女性（比值比[OR]，1.43；95%置信区间[CI]，1.06 - 1.92；P = 0.02）、华裔种族/民族（OR，3.58；95% CI，2.03 - 6.29；P < 0.001）、眼轴长度（每增加1毫米的OR，0.69；95% CI，0.58 - 0.81；P < 0.001）以及中央前房深度小于2.80毫米与至少3.00毫米相比（OR，42.5；95% CI，27.4 - 66.2；P < 0.001）与AC独立相关。
在这项基于社区的新加坡老年人研究中，可以通过统计学显著独立预测AC的因素为女性、较短的眼轴长度、较浅的中央前房深度以及华裔种族/民族。AC风险中的性别和种族/民族差异不能完全用眼轴长度或前房深度的性别和种族/民族差异来解释。
