Department of Veterinary Basic Sciences The Royal Veterinary College Hawkshead Lane North Mymms, Hertfordshire AL9 7TA UK.
Mediators Inflamm. 1992;1(1):55-9. doi: 10.1155/S0962935192000115.
Nicotinates and benzalkonium chloride (B.Cl) cause inflammatory changes in human skin, thought to be dependent upon prostaglandin formation. This study has examined the effects of hexyl-nicotinate (HN) and B.Cl on blood flow in porcine skin. The role of prostaglandins and interleukin (IL)-1 in the blood flow response has been investigated. Blood flow was increased by both HN and B.Cl, the response to B.Cl being more protracted. Cyclooxygenase inhibitor pretreatment reduced these responses. IL-1-like biological activity was identified in normal porcine epidermis and the amounts recovered from inflamed skin were similar. Thus prostaglandin formation in HN or B.Cl-induced inflammation, if IL-1 dependent, is not associated with the loss of significant amounts of the cytokine from the epidermis.
烟酸盐和苯扎氯铵(B.Cl)会引起人体皮肤的炎症变化,据认为这与前列腺素的形成有关。本研究检测了己基烟酸盐(HN)和 B.Cl 对猪皮血流量的影响。还研究了前列腺素和白细胞介素(IL)-1在血流反应中的作用。HN 和 B.Cl 均可增加血流量,B.Cl 的反应更为持久。环氧化酶抑制剂预处理可减少这些反应。在正常猪表皮中鉴定出具有 IL-1 样生物活性的物质,从发炎皮肤中回收的物质数量相似。因此,HN 或 B.Cl 诱导的炎症中前列腺素的形成(如果依赖于 IL-1)与表皮中大量细胞因子丢失无关。