巨噬细胞细胞因子与类花生酸在抗肿瘤活性表达中的相互作用。
Interactions between rnacrophage cytokines and eicosanoids in expression of antitumour activity.
机构信息
Department of Pharmacology Faculty of Medicine Erasmus University Rotterdam 3000 DR The Netherlands.
出版信息
Mediators Inflamm. 1992;1(5):295-308. doi: 10.1155/S0962935192000449.
Abstract
Cytokines and eicosanoid products of macrophages play an essential role in expression of antitumour activity of macrophages either in a cell-to-cell contact system between the effector and the target cell or as cell-free soluble products. In this review the relationship between three main monokines, namely TNF-alpha, IL-1 and IL-6 and the interrelationship between these monokines and eicosanoids (PGE(2), PGI(2), LTB(4), LTC(4)) in their production and in expression of antitumour activity is discussed. Emphasis is given to the effect of tumour burden on production of the monokines and of the eicosanoids and on the production of these compounds by the tumour cells. Finally, the therapeutic implications drawn from animal studies and clinical trials is discussed.
摘要
巨噬细胞的细胞因子和类二十烷酸产物在效应细胞与靶细胞之间的细胞接触系统或作为无细胞可溶性产物中发挥抗肿瘤活性方面发挥着重要作用。在这篇综述中，讨论了三种主要的单核因子，即 TNF-α、IL-1 和 IL-6，以及这些单核因子与类二十烷酸（PGE（2）、PGI（2）、LTB（4）、LTC（4））之间在产生和表达抗肿瘤活性方面的相互关系。重点讨论了肿瘤负担对单核因子和类二十烷酸产物的产生以及肿瘤细胞产生这些化合物的影响。最后，讨论了从动物研究和临床试验中得出的治疗意义。
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