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本文引用的文献

1
Prostaglandin regulation of macrophage function: effect of endogenous and exogenous prostaglandins.前列腺素对巨噬细胞功能的调节：内源性和外源性前列腺素的作用
Cell Immunol. 1982 Dec;74(2):234-42. doi: 10.1016/0008-8749(82)90024-7.
2
Prostaglandin in human breast cancer: Evidence suggesting that an elevated prostaglandin production is a marker of high metastatic potential for neoplastic cells.前列腺素与人类乳腺癌：有证据表明，前列腺素生成增加是肿瘤细胞高转移潜能的一个标志。
J Natl Cancer Inst. 1980 May;64(5):1061-70.
3
Ability of cancer patients' macrophages to kill autologous tumor targets. Effect of prostaglandin inhibitors on cytotoxicity.癌症患者巨噬细胞杀伤自体肿瘤靶标的能力。前列腺素抑制剂对细胞毒性的影响。
Cancer. 1984 May 15;53(10):2053-7. doi: 10.1002/1097-0142(19840515)53:10<2053::aid-cncr2820531008>3.0.co;2-k.
4
Amplification by macrophages of prostaglandin-mediated immunosuppression in mice bearing syngeneic tumors.巨噬细胞对携带同基因肿瘤小鼠中前列腺素介导的免疫抑制的放大作用。
Prostaglandins Leukot Med. 1984 Nov;16(2):205-23. doi: 10.1016/0262-1746(84)90072-6.
5
The ability of macrophages from head and neck cancer patients to kill tumor cells. Effect of prostaglandin inhibitors on cytotoxicity.头颈癌患者巨噬细胞杀伤肿瘤细胞的能力。前列腺素抑制剂对细胞毒性的影响。
Cancer. 1984 Dec 1;54(11):2403-8. doi: 10.1002/1097-0142(19841201)54:11<2403::aid-cncr2820541116>3.0.co;2-f.
6
Antitumor activity of murine tumor necrosis factor (TNF) against transplanted murine tumors and heterotransplanted human tumors in nude mice.小鼠肿瘤坏死因子（TNF）对裸鼠体内移植的小鼠肿瘤和异种移植的人类肿瘤的抗肿瘤活性。
Int J Cancer. 1984 Aug 15;34(2):263-7. doi: 10.1002/ijc.2910340219.
7
The influence of lipoxygenase inhibitors on the in vitro production of human leukocytic pyrogen and lymphocyte activating factor (interleukin-1).脂氧合酶抑制剂对人白细胞致热原及淋巴细胞激活因子（白细胞介素-1）体外产生的影响。
Int J Immunopharmacol. 1984;6(1):43-50. doi: 10.1016/0192-0561(84)90033-x.
8
Regulation of macrophage-mediated tumor cell killing by prostaglandins: comparison of the effects of PGE2 and PGI2.前列腺素对巨噬细胞介导的肿瘤细胞杀伤作用的调节：PGE2和PGI2作用的比较
Prostaglandins. 1982 Dec;24(6):763-74. doi: 10.1016/0090-6980(82)90057-0.
9
Prostaglandins and cancer: a review of tumor initiation through tumor metastasis.前列腺素与癌症：肿瘤起始至转移的综述
Prostaglandins. 1981 May;21(5):833-64. doi: 10.1016/0090-6980(81)90240-9.
10
Unique aspects of the modulation of human neutrophil function by 12-L-hydroperoxy-5,8,10,14-eicosatetraenoic acid.12-L-氢过氧-5,8,10,14-二十碳四烯酸对人中性粒细胞功能调节的独特方面
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巨噬细胞细胞因子与类花生酸在抗肿瘤活性表达中的相互作用。

Interactions between rnacrophage cytokines and eicosanoids in expression of antitumour activity.

机构信息

Department of Pharmacology Faculty of Medicine Erasmus University Rotterdam 3000 DR The Netherlands.

出版信息

Mediators Inflamm. 1992;1(5):295-308. doi: 10.1155/S0962935192000449.

DOI:10.1155/S0962935192000449
PMID:18475475
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC2365362/
Abstract

Cytokines and eicosanoid products of macrophages play an essential role in expression of antitumour activity of macrophages either in a cell-to-cell contact system between the effector and the target cell or as cell-free soluble products. In this review the relationship between three main monokines, namely TNF-alpha, IL-1 and IL-6 and the interrelationship between these monokines and eicosanoids (PGE(2), PGI(2), LTB(4), LTC(4)) in their production and in expression of antitumour activity is discussed. Emphasis is given to the effect of tumour burden on production of the monokines and of the eicosanoids and on the production of these compounds by the tumour cells. Finally, the therapeutic implications drawn from animal studies and clinical trials is discussed.

摘要

巨噬细胞的细胞因子和类二十烷酸产物在效应细胞与靶细胞之间的细胞接触系统或作为无细胞可溶性产物中发挥抗肿瘤活性方面发挥着重要作用。在这篇综述中，讨论了三种主要的单核因子，即 TNF-α、IL-1 和 IL-6，以及这些单核因子与类二十烷酸（PGE（2）、PGI（2）、LTB（4）、LTC（4））之间在产生和表达抗肿瘤活性方面的相互关系。重点讨论了肿瘤负担对单核因子和类二十烷酸产物的产生以及肿瘤细胞产生这些化合物的影响。最后，讨论了从动物研究和临床试验中得出的治疗意义。