5th Paediatric Department University of Milan Via Rossini, 2 Milan 20062 Italy.
Mediators Inflamm. 1994;3(7):S43-7. doi: 10.1155/S096293519400075X.
The purpose of this study was to evaluate whether nedocromil sodium benefits urban asthmatic children showing seasonal bronchial hyper-reactivity to ultrasonic nebulization of distilled water (UNDW). A prospective, randomized, placebo-controlled, parallel-group, double-blind study was carried out at the outpatient pulmonology service at a tertiary-care teaching hospital. Twelve children living in Milan, who were 7-17 years of age, who were SPT and RAST-negative to perennial allergens, who were suffering from episodic asthma, and showing seasonal bronchial hyper-reactivity to UNDW during winter, participated in this study. All the children received either placebo or nedocromil sodium, 4 mg every 6 h for 6 weeks. Spirometry and UNDW challenge were done at the following times: day-7; day 0; day 1; day 7; day 14; day 28; day 42. No differences were found in the basal spirometric parameters, which were normal in both nedocromil and placebo groups. Bronchial reactivity to UNDW was found to be significantly decreased in the group treated with nedocromtl starting from day 7. It is therefore concluded that nedocromil sodium can reverse bronchial hyper-reactivity caused by seasonal factors such as cold, viral infections and atmospheric pollutants in children suffering from asthma.
本研究旨在评估奈多罗米钠对超声雾化蒸馏水（UNDW）显示季节性支气管高反应性的城市哮喘儿童是否有益。在一所三级教学医院的门诊肺病科进行了一项前瞻性、随机、安慰剂对照、平行组、双盲研究。12 名居住在米兰的 7-17 岁儿童参加了这项研究，他们对常年过敏原 SPT 和 RAST 均为阴性，患有间歇性哮喘，且在冬季对 UNDW 表现出季节性支气管高反应性。所有儿童均接受安慰剂或奈多罗米钠治疗，每天 6 小时 4 毫克，共 6 周。在以下时间进行肺量测定和 UNDW 挑战：第-7 天；第 0 天；第 1 天；第 7 天；第 14 天；第 28 天；第 42 天。奈多罗米钠组和安慰剂组的基础肺功能参数均未见差异，均在正常范围内。从第 7 天开始，用奈多罗米钠治疗的组发现对 UNDW 的支气管反应性显著降低。因此，结论是奈多罗米钠可以逆转哮喘儿童因寒冷、病毒感染和大气污染物等季节性因素引起的支气管高反应性。
