Reedy M B, Sulak P J, Miller S L, Ortiz M, Kasberg-Preece C, Kuehl T J
Department of Obstetrics and Gynecology Scott & White Clinic 1600 University Drive East College Station TX 77840 USA.
Infect Dis Obstet Gynecol. 1997;5(1):18-22. doi: 10.1155/S1064744997000069.
The purpose of this study was to compare the efficacy of a 3-day course of doxycycline to a standard 7-day course for treating uncomplicated chlamydia cervicitis.
During an 18-month period, 77 women with uncomplicated chlamydia cervicitis were randomized to receive either a 3-day or a 7-day course of doxycycline (100 mg twice daily). Tests of cure were performed 3 weeks after completion of therapy with the Amplicor polymerase chain reaction (PCR) assay (Roche Molecular Systems, Branchburg, NJ). Demographics, therapeutic results, and side effects for the two groups were compared.
Seventy-three patients completed the study: 35 in the 3-day group and 38 in the 7-day group. There were no significant differences in age, gravidity, or parity between the groups. There was a 94% (33/35) cure rate in the 3-day group and a 95% (36/38) cure rate in the 7-day group (P = 1.0). Thirty-four percent and 32% of the patients in the 3- and 7-day groups reported side effects, respectively; there was no significant differences between the 3- and 7-day groups in regard to population demographics, patient compliance, therapeutic outcome, or side effects.
A 3-day course of doxycycline appears to be as effective as a 7-day course of doxycycline for the treatment of uncomplicated chlamydia cervicitis.
本研究旨在比较多西环素3日疗程与标准7日疗程治疗单纯性衣原体宫颈炎的疗效。
在18个月期间，77例单纯性衣原体宫颈炎女性被随机分为两组，分别接受多西环素3日疗程（每日2次，每次100mg）或7日疗程治疗。治疗结束3周后，采用罗氏分子系统公司（位于新泽西州布兰奇堡）的Amplicor聚合酶链反应（PCR）检测法进行治愈检测。比较两组的人口统计学特征、治疗结果和副作用。
73例患者完成研究，3日疗程组35例，7日疗程组38例。两组在年龄、妊娠次数或产次方面无显著差异。3日疗程组治愈率为94%（33/35），7日疗程组治愈率为95%（36/38）（P = 1.0）。3日疗程组和7日疗程组分别有34%和32%的患者报告有副作用；两组在人口统计学特征、患者依从性、治疗结果或副作用方面无显著差异。
多西环素3日疗程治疗单纯性衣原体宫颈炎的疗效似乎与7日疗程相当。
