Zervoudis Stefanos, Iatrakis Georgios, Eskitzis Panagiotis, Markja Anisa, Michou Vasiliki, Balafouta Myrsini, Kyrkou Giannoula, Tsikouras Panagiotis
University of West Attica (UniWA), Athens, Greece.
Rea Maternity Hospital, Athens, Greece.
Maedica (Bucur). 2025 Mar;20(1):11-18. doi: 10.26574/maedica.2025.20.1.11.
Cervicitis is commonly caused by sexually transmitted infections. This study compares the standard antibiotic treatment with antibiotics plus cryocoagulation in cases of chronic and hemorrhagic cervicitis. Although antibiotics are typically the first line of treatment, persistent cases often require additional interventions, like cryosurgery to obtain a cure. Fifty women (mean age 38 years) with chronic cervicitis - based on clinical evaluations, cytology and vaginal culture - were enrolled in the present study. Twenty three participants were treated with combination therapy consisting of an initial course of antibiotics, followed by cryocoagulation and a subsequent round of antibiotics post-procedure, using a "sandwich" technique, while 27 subjects received antibiotics alone. Our study showed that the "sandwich" technique achieved a success rate of 76.2% (p<0.005) after a single session for treating chronic cervicitis and hemorrhagic cervicitis (normalization in Pap smear) and 95.7% (p<0.05) success rate in clinical improvement after intervention. The combination of antibiotic treatment followed by cryosurgery and then another prophylactic course of antibiotics presents a promising approach for managing chronic cervicitis and recurrent cervical hemorrhage.
宫颈炎通常由性传播感染引起。本研究比较了慢性和出血性宫颈炎病例中标准抗生素治疗与抗生素联合冷冻凝固治疗的效果。尽管抗生素通常是一线治疗方法，但持续性病例往往需要额外的干预措施，如冷冻手术才能治愈。本研究纳入了50名（平均年龄38岁）基于临床评估、细胞学检查和阴道培养确诊为慢性宫颈炎的女性。23名参与者采用联合治疗，即采用“三明治”技术，先进行一个疗程的抗生素治疗，然后进行冷冻凝固，术后再进行一轮抗生素治疗；而27名受试者仅接受抗生素治疗。我们的研究表明，“三明治”技术单次治疗慢性宫颈炎和出血性宫颈炎（巴氏涂片正常化）的成功率为76.2%（p<0.005），干预后临床改善的成功率为95.7%（p<0.05）。抗生素治疗后进行冷冻手术，然后再进行一个预防性抗生素疗程的联合治疗，为管理慢性宫颈炎和复发性宫颈出血提供了一种有前景的方法。
