单剂量口服头孢克肟治疗妊娠期淋病的安全性和有效性开放性研究。
Open study of the safety and efficacy of a single oral dose of cefixime for the treatment of gonorrhea in pregnancy.
作者信息
Miller J M
机构信息
Department of Obstetrics and Gynecology Louisiana State University Medical Center 1542 Tulane Avenue New Orleans LA USA.
出版信息
Infect Dis Obstet Gynecol. 1997;5(3):259-61. doi: 10.1155/S1064744997000434.
OBJECTIVE
The intent of this study was to determine the efficacy and tolerance of single dose oral cefixime use in the treatment of pregnant women with endocervical gonococcal carriage.
METHODS
A retrospective review of clinic records over a 3 year period identified patients treated with a single 400 mg dose of cefixime for gonorrhea during pregnancy. Side effects and subsequent gonococcal carriage were noted.
RESULTS
Pregnant women (n = 102) treated with cefixime were reviewed. A cure rate of 95.2% was found. Side effects were reported in three patients: two had nausea and vomiting and one had diarrhea.
CONCLUSIONS
A single 400 mg oral dose of cefixime was effective for the treatment of gonorrhea and was well tolerated by the pregnant women.
目的
本研究旨在确定单剂量口服头孢克肟治疗宫颈淋病奈瑟菌携带孕妇的疗效和耐受性。
方法
对3年期间的临床记录进行回顾性分析，确定孕期接受单次400mg剂量头孢克肟治疗淋病的患者。记录副作用及随后的淋病奈瑟菌携带情况。
结果
对102例接受头孢克肟治疗的孕妇进行了评估。治愈率为95.2%。有3例报告了副作用：2例出现恶心和呕吐，1例出现腹泻。
结论
单次口服400mg头孢克肟治疗淋病有效，且孕妇耐受性良好。
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