School of Pharmaceutical Sciences, Institute of Medical, Pharmaceutical and Health Sciences, Kanazawa University, Kakuma-machi, Kanazawa 920-1192, Japan.
Org Lett. 2010 Jan 1;12(1):124-6. doi: 10.1021/ol902510p.
Sequential steps that involved radical addition of a nitro group to 1,6-dienes promoted by the thermal decomposition of iron nitrate(III) nonahydrate, cyclization, and trapping of the resulting terminal radicals by a chlorine atom in the presence of chloride salt afforded five-membered-ring compounds. The present reaction provides a practical method for the synthesis of nitro compounds due to its simple experimental procedure and its use of nontoxic and inexpensive iron reagents.
依次涉及硝基基团的自由基加成到 1,6-二烯的步骤，该步骤由硝酸铁(III)九水合物的热分解促进，环化，以及在存在氯化物盐的情况下，由氯原子捕获生成的末端自由基，得到五元环化合物。由于其简单的实验程序和使用无毒且廉价的铁试剂，本反应为硝基化合物的合成提供了一种实用的方法。
