Chuang Helen F, Smith Reneé C, Hammond Paula T
Department of Chemical Engineering, Massachusetts Institute of Technology, Cambridge, Massachusetts 02139, USA.
Biomacromolecules. 2008 Jun;9(6):1660-8. doi: 10.1021/bm800185h. Epub 2008 May 14.
Polyelectrolyte multilayers incorporating gentamicin were fabricated using layer-by-layer deposition. The multilayers could be precisely tuned with regard to dosage, and release rate under aqueous physiological conditions could be controlled. The films were demonstrated efficacious against Staphylococcus aureus and nontoxic toward murine osteoblasts MC3T3. The films were made in a layer-by-layer process with a heterostructural architecture that represents a general strategy for incorporating charged small molecular species into polyelectrolyte multilayers without the need for any physical or chemical premodification, expanding the range of active species that can be delivered from these films while maintaining the ease of layer-by-layer fabrication process.
采用层层沉积法制备了含有庆大霉素的聚电解质多层膜。多层膜在剂量方面可以精确调节，并且在生理水性条件下的释放速率也能够得到控制。这些薄膜对金黄色葡萄球菌显示出有效性，并且对小鼠成骨细胞MC3T3无毒。这些薄膜是通过层层工艺制成的，具有异质结构，这代表了一种将带电小分子物种纳入聚电解质多层膜的通用策略，无需任何物理或化学预改性，在保持层层制造工艺简便性的同时，扩大了可以从这些薄膜中递送的活性物种的范围。
