Wang Dan, Zhang Jianfu, Zhong Yingjie, Chu Ming, Chang Wenyang, Yao Zhanhai
School of Chemistry and Environmental Engineering, Changchun University of Science and Technology Changchun 130022 P. R. China
State Key Laboratory of Polymer Physics and Chemistry, Changchun Institute of Applied Chemistry Chinese Academy of Sciences Changchun 130022 P. R. China.
RSC Adv. 2018 May 22;8(34):18904-18912. doi: 10.1039/c8ra03214a.
The development of mussel-inspired materials with enhanced mechanical and physiological characteristics is fascinating due to the resulting structural properties. In this work, based on a chemical reaction, 3-(3,4-dihydroxyphenyl)propionic acid and dopamine hydrochloride (DA), with a catechol group, were covalently grafted onto a bio-compatible polymer backbone of chitosan hydrochloride (CHI) and hyaluronic acid sodium (HA). A mussel-inspired water-resistant adhesive film that could adhere in water was then fabricated by an environmentally friendly layer-by-layer (LbL) process. The water-resistant adhesive film demonstrated a strong underwater mechanical connection (0.82 ± 0.19 MPa) and a high transmittance (more than 83%) in the visible region; these characteristics are beneficial for clinical observation. A free-standing water-resistant adhesive film with a high transmittance of over 83% was also demonstrated and obtained from a facial and effective mechanical exfoliation method. The free-standing film exhibited favorable adhesion capacity with porcine skin, making it attractive for applications in the biomedical field.
由于所得的结构特性，开发具有增强的机械和生理特性的贻贝启发材料很有吸引力。在这项工作中，基于化学反应，将具有儿茶酚基团的3-(3,4-二羟基苯基)丙酸和盐酸多巴胺(DA)共价接枝到盐酸壳聚糖(CHI)和透明质酸钠(HA)的生物相容性聚合物主链上。然后通过环境友好的层层(LbL)工艺制备了一种能在水中粘附的贻贝启发型防水粘附膜。该防水粘附膜在可见光区域表现出很强的水下机械连接性(0.82±0.19 MPa)和高透光率(超过83%)；这些特性有利于临床观察。还通过一种面部有效机械剥离方法展示并获得了一种透光率超过83%的独立式防水粘附膜。该独立式膜对猪皮表现出良好的粘附能力，使其在生物医学领域的应用具有吸引力。
