Chen Fuqiang, Li Qingshu, Yu Yang, Yang Wenrong, Shi Fei, Qu Yan
Department of Pain Management, Qingdao Municipal Hospital, Qingdao, China.
Intensive Care Unit, Qingdao Municipal Hospital, Qingdao, China.
Sci Rep. 2015 Apr 23;5:9599. doi: 10.1038/srep09599.
A dose-response meta-analysis was conducted to assess the association of vitamin C, D, E with risk of bladder cancer. Pertinent studies were identified in PubMed and Embase. The random-effect model was used. The relative risk (95% confidence interval) of bladder cancer was 0.99 (0.95-1.03) for every 100 IU/day increment in vitamin D from diet plus supplement and 0.95 (0.90-1.00) for every 10 nmol/L increment in circulating vitamin D. The effect for every 10 mg/day increment was 0.96 (0.90-1.02) for vitamin E from diet plus supplement, 0.83 (0.72-0.95) from diet and 0.88 (0.67-1.15) from supplement, and the effect was 0.84 (0.76-0.94) for every 1 mg/dL increment in circulating α-Tocopherol and 1.22 (1.00-1.49) for every 0.1 mg/dL increment in circulating γ-Tocopherol. The observed association for vitamin D and vitamin E was significant among smokers but not among non-smokers. No significant association was found between vitamin C and risk of bladder cancer in the dose-response analysis. Based on the dose-response analysis, the risk of bladder cancer might be inversely associated with vitamin D and E (especially α-Tocopherol), but positively associated with γ-Tocopherol.
进行了一项剂量反应荟萃分析，以评估维生素C、D、E与膀胱癌风险之间的关联。在PubMed和Embase中检索相关研究。采用随机效应模型。饮食加补充剂中维生素D每增加100 IU/天，膀胱癌的相对风险（95%置信区间）为0.99（0.95 - 1.03）；循环维生素D每增加10 nmol/L，相对风险为0.95（0.90 - 1.00）。饮食加补充剂中维生素E每增加10 mg/天的效应为0.96（0.90 - 1.02），饮食中为0.83（0.72 - 0.95），补充剂中为0.88（0.67 - 1.15）；循环α-生育酚每增加1 mg/dL的效应为0.84（0.76 - 0.94），循环γ-生育酚每增加0.1 mg/dL的效应为1.22（1.00 - 1.49）。在吸烟者中观察到的维生素D和维生素E的关联具有显著性，但在非吸烟者中不显著。在剂量反应分析中，未发现维生素C与膀胱癌风险之间存在显著关联。基于剂量反应分析，膀胱癌风险可能与维生素D和E（尤其是α-生育酚）呈负相关，但与γ-生育酚呈正相关。
