细胞控制系统中的正反馈。
Positive feedback in cellular control systems.
作者信息
Mitrophanov Alexander Y, Groisman Eduardo A
机构信息
Howard Hughes Medical Institute, Department of Molecular Microbiology, Washington University School of Medicine, St. Louis, MO 63110, USA.
出版信息
Bioessays. 2008 Jun;30(6):542-55. doi: 10.1002/bies.20769.
Abstract
Feedback loops have been identified in a variety of regulatory systems and organisms. While feedback loops of the same type (negative or positive) tend to have properties in common, they can play distinctively diverse roles in different regulatory systems, where they can affect virulence in a pathogenic bacterium, maturation patterns of vertebrate oocytes and transitions through cell cycle phases in eukaryotic cells. This review focuses on the properties and functions of positive feedback in biological systems, including bistability, hysteresis and activation surges.
摘要
反馈回路已在各种调节系统和生物体中被识别出来。虽然同一类型（负反馈或正反馈）的反馈回路往往具有共同的特性，但它们在不同的调节系统中可以发挥截然不同的作用，在这些系统中，它们可以影响致病细菌的毒力、脊椎动物卵母细胞的成熟模式以及真核细胞中细胞周期各阶段的转换。本综述重点关注生物系统中正反馈的特性和功能，包括双稳态、滞后现象和激活激增。
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