Guitton Matthieu J, Klin Yael, Dudai Yadin
Department of Neurobiology, The Weizmann Institute of Science, Rehovot 76100, Israel.
Behav Brain Res. 2008 Aug 22;191(2):148-52. doi: 10.1016/j.bbr.2008.03.022. Epub 2008 Mar 25.
Using a combination of the paradigm of conditioned taste aversion (CTA) and of the paradigm of social interactions, we report here that in the rat, eating while anxious may result in long-term alterations in social behavior. In the conventional CTA, the subject learns to associate a tastant (the conditioned stimulus, CS) with delayed toxicosis (an unconditioned stimulus, UCS) to yield taste aversion (the conditioned response, CR). However, the association of taste with delayed negative internal states that could generate CRs that are different from taste aversion should not be neglected. Such associations may contribute to the ontogenesis, reinforcement and symptoms of some types of taste- and food-related disorders. We have recently reported that a delayed anxiety-like state, induced by the anxiogenic drug meta-chlorophenylpiperazine (mCPP), can specifically associate with taste to produce CTA. We now show that a similar protocol results in a marked lingering impairment in social interactions in response to the conditioned taste. This is hence a learned situation in which food and company do not mix well.
通过结合条件性味觉厌恶（CTA）范式和社交互动范式，我们在此报告，在大鼠中，焦虑时进食可能会导致社交行为的长期改变。在传统的CTA中，实验对象学会将一种味觉刺激（条件刺激，CS）与延迟的中毒反应（非条件刺激，UCS）联系起来，从而产生味觉厌恶（条件反应，CR）。然而，味觉与延迟的负面内部状态之间的关联也不应被忽视，这种关联可能会产生与味觉厌恶不同的CR。此类关联可能会促成某些类型的味觉和食物相关障碍的发生、强化及症状表现。我们最近报告称，由致焦虑药物间氯苯哌嗪（mCPP）诱发的延迟性焦虑样状态可特异性地与味觉联系起来，从而产生CTA。我们现在表明，类似的实验方案会导致对条件性味觉的社交互动出现明显的持续性损害。因此，这是一种习得的情况，即食物和同伴不能很好地融合。
