原发性局灶性肌张力障碍和帕金森病中的精神障碍。
Psychiatric disorders in primary focal dystonia and in Parkinson's disease.
机构信息
Neuropsychiatric Branch.
出版信息
Neuropsychiatr Dis Treat. 2011;7:111-6. doi: 10.2147/NDT.S17507. Epub 2011 Mar 14.
BACKGROUND
Primary focal dystonia and Parkinson's disease are movement disorders that have contrasting motor phenotypes. The aim of this study was to compare the frequency and the severity of psychiatric disorders in primary focal dystonia and Parkinson's disease.
METHODS
Two groups of 30 patients matched by gender and age underwent a neurological and psychiatric assessment.
RESULTS
Parkinson's disease patients were diagnosed with higher rates of major depression (P = 0.02) and generalized anxiety disorder (P = 0.02), and greater severity of depressive symptoms (P = 0.04), while patients with primary focal dystonia exhibited increased severity of obsessive-compulsive symptoms (P = 0.02).
DISCUSSION
The difference in pathophysiology of primary focal dystonia and Parkinson's disease may explain the different psychiatric profiles of these two diseases. The increased frequency of affective symptoms in Parkinson's disease may be related to the fact that Parkinson's disease is a neurodegenerative disease marked by the loss of monoaminergic neurons which does not happen in primary focal dystonia.
CONCLUSION
The psychiatric profile differs in movement disorders with distinct neurobiological bases.
背景
原发性局灶性肌张力障碍和帕金森病是具有不同运动表现的运动障碍。本研究旨在比较原发性局灶性肌张力障碍和帕金森病患者精神障碍的频率和严重程度。
方法
两组 30 名患者按性别和年龄匹配，进行神经和精神评估。
结果
帕金森病患者被诊断为重度抑郁症（P = 0.02）和广泛性焦虑症（P = 0.02）的发生率较高，抑郁症状的严重程度也更高（P = 0.04），而原发性局灶性肌张力障碍患者的强迫症状严重程度增加（P = 0.02）。
讨论
原发性局灶性肌张力障碍和帕金森病的病理生理学差异可能解释了这两种疾病不同的精神障碍特征。帕金森病中情感症状的发生率增加可能与帕金森病是一种神经退行性疾病有关，其特征是单胺能神经元丧失，而原发性局灶性肌张力障碍则没有这种情况。
结论
具有不同神经生物学基础的运动障碍的精神障碍特征不同。
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