Cai Chen-Leng, Martin Jody C, Sun Yunfu, Cui Li, Wang Lianchun, Ouyang Kunfu, Yang Lei, Bu Lei, Liang Xingqun, Zhang Xiaoxue, Stallcup William B, Denton Christopher P, McCulloch Andrew, Chen Ju, Evans Sylvia M
Skaggs School of Pharmacy, University of California, San Diego, La Jolla, California 92093, USA.
Nature. 2008 Jul 3;454(7200):104-8. doi: 10.1038/nature06969. Epub 2008 May 14.
Understanding the origins and roles of cardiac progenitor cells is important for elucidating the pathogenesis of congenital and acquired heart diseases. Moreover, manipulation of cardiac myocyte progenitors has potential for cell-based repair strategies for various myocardial disorders. Here we report the identification in mouse of a previously unknown cardiac myocyte lineage that derives from the proepicardial organ. These progenitor cells, which express the T-box transcription factor Tbx18, migrate onto the outer cardiac surface to form the epicardium, and then make a substantial contribution to myocytes in the ventricular septum and the atrial and ventricular walls. Tbx18-expressing cardiac progenitors also give rise to cardiac fibroblasts and coronary smooth muscle cells. The pluripotency of Tbx18 proepicardial cells provides a theoretical framework for applying these progenitors to effect cardiac repair and regeneration.
了解心脏祖细胞的起源和作用对于阐明先天性和后天性心脏病的发病机制至关重要。此外，操控心肌祖细胞对于各种心肌疾病基于细胞的修复策略具有潜在意义。在此，我们报告在小鼠中鉴定出一种先前未知的源自心外膜器官的心肌细胞谱系。这些表达T盒转录因子Tbx18的祖细胞迁移到心脏外表面形成心外膜，然后对室间隔以及心房和心室壁中的心肌细胞做出重大贡献。表达Tbx18的心脏祖细胞还可产生心脏成纤维细胞和冠状动脉平滑肌细胞。Tbx18心外膜细胞的多能性为应用这些祖细胞实现心脏修复和再生提供了理论框架。
