真菌次级代谢组的表观遗传重塑
Epigenetic remodeling of the fungal secondary metabolome.
作者信息
Williams Russell B, Henrikson Jon C, Hoover Ashley R, Lee Andrlynn E, Cichewicz Robert H
机构信息
Natural Products Discovery Group, Department of Chemistry and Biochemistry, 620 Parrington Oval, Room 208, University of Oklahoma, Norman, Oklahoma 73019-3032, USA.
出版信息
Org Biomol Chem. 2008 Jun 7;6(11):1895-7. doi: 10.1039/b804701d. Epub 2008 Apr 14.
Fungi treated with DNA methyltransferase and histone deacetylase inhibitors exhibited natural product profiles with enhanced chemical diversity demonstrating that small-molecule epigenetic modifiers are effective tools for rationally controlling the native expression of fungal biosynthetic pathways and generating new biomolecules.
用DNA甲基转移酶和组蛋白脱乙酰酶抑制剂处理的真菌表现出具有增强化学多样性的天然产物谱，这表明小分子表观遗传修饰剂是合理控制真菌生物合成途径的天然表达并产生新生物分子的有效工具。
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