Kang Shi-Jie, Zhao Ling, Wang Haiqiang, Gao Jin-Ming, Qi Jianzhao
Shaanxi Key Laboratory of Natural Products & Chemical Biology, College of Chemistry & Pharmacy, Northwest A&F University, Yangling, China.
Department of Pharmacy, School of Medicine, Xi'an International University, Xi'an, China.
Mycology. 2024 Apr 24;15(3):322-344. doi: 10.1080/21501203.2024.2341648. eCollection 2024.
The family Diatrypaceae is a less well-known group within the order Xylariales (Ascomycota). Initially, the focus on its metabolites was related to the pathogenicity of one of its members, . To date, a total of 254 natural products have been identified from Diatrypaceae strains. These compounds include terpenoids, sterols, polyketones, phenols, and acetylene aromatic compounds, which have shown anticancer, cytotoxic, anti-inflammatory, antimicrobial, and antiviral activities. The complex and diverse structural types, along with the diverse bioactivities, highlight the potential of Diatrypaceae as a valuable source of bioactive natural products. In this review, a deep analysis of the biosynthesis of pimarane diterpenes and scoparasin-type cytochalasins is provided, coupled with a compilation of the biosynthetic pathways of aromatic acetylene compounds in filamentous fungi. This comprehensive review not only enhances our understanding of the natural product chemistry, biological activities, and biosynthesis of secondary metabolites from the Diatrypaceae family but also promotes the exploitation and development of important bioactive compounds and potential strains.
炭角菌科是炭角菌目（子囊菌门）中一个不太知名的类群。最初，对其代谢产物的关注与该类群中的一个成员的致病性有关。迄今为止，已从炭角菌科菌株中鉴定出总共254种天然产物。这些化合物包括萜类、甾醇、聚酮化合物、酚类和乙炔芳香化合物，它们已显示出抗癌、细胞毒性、抗炎、抗菌和抗病毒活性。复杂多样的结构类型以及多样的生物活性，凸显了炭角菌科作为生物活性天然产物宝贵来源的潜力。在本综述中，对海松烷二萜和scoparasin型细胞松弛素的生物合成进行了深入分析，并汇编了丝状真菌中芳香乙炔化合物的生物合成途径。这一全面综述不仅增进了我们对炭角菌科天然产物化学、生物活性和次生代谢物生物合成的理解，还促进了重要生物活性化合物和潜在菌株的开发与利用。
