Kim Hyun Jung, Kim So-Hyun, Kang Bok Yun, Lee Ik-Soo
College of Pharmacy and Research Institute of Drug Development, Chonnam National University, Gwangju 500-757, Korea.
Arch Pharm Res. 2008 Oct;31(10):1241-6. doi: 10.1007/s12272-001-2102-5. Epub 2008 Oct 29.
Microbial metabolism studies of the phyto-estrogen (+/-)-8-prenylnaringenin (8-PN) (1) has led to the isolation of three pairs of metabolites (2-4). The structures of these compounds were identified as 5,4'-dihydroxy-7,8-[2-(1-hydroxy-1-methylethyl)-2,3-dihydrofurano]flavanones (2), 8-prenylnaringenin 7-O-beta-D-glucopyranosides (3), and 8-prenylnaringenin 7-O-beta-D-(6'''-O-alpha-hydroxypropionyl)-glucopyranosides (4) on the basis of the spectroscopic analysis.
对植物雌激素（±）-8-异戊烯基柚皮素（8-PN）（1）的微生物代谢研究已分离出三对代谢产物（2-4）。基于光谱分析，这些化合物的结构被鉴定为5,4'-二羟基-7,8-[2-(1-羟基-1-甲基乙基)-2,3-二氢呋喃]黄酮（2）、8-异戊烯基柚皮素7-O-β-D-吡喃葡萄糖苷（3）和8-异戊烯基柚皮素7-O-β-D-（6'''-O-α-羟基丙酰基）-吡喃葡萄糖苷（4）。
