Van Dyke Susan, Hays Geoffrey P, Caglia Anthony E, Caglia Michael
J Clin Aesthet Dermatol. 2010 May;3(5):32-5.
Injectable fillers are normally well tolerated by patients with little or no adverse effects. The most common side effects include swelling, redness, bruising, and pain at the injection site. This report describes three cases in which patients injected with a hyaluronic acid-derived injectable filler that is premixed with lidocaine developed adverse reactions including persistent swelling, pain, and nodule formation. Two of the three patients' abscesses were cultured for aerobic and anaerobic bacteria and mycobacterium. All three cultures were negative. Abscess persistence in all cases necessitated physical removal and/or enzymatic degradation with hyaluronidase. The effects subsided only after the product had been removed. Two of these patients were subsequently treated with other hyaluronic acid-derived dermal fillers without adverse events.
可注射填充剂通常耐受性良好，患者很少或几乎没有不良反应。最常见的副作用包括注射部位肿胀、发红、瘀伤和疼痛。本报告描述了三例患者，他们注射了一种预先与利多卡因混合的透明质酸衍生可注射填充剂后出现了不良反应，包括持续性肿胀、疼痛和结节形成。对三名患者中的两名患者的脓肿进行了需氧菌、厌氧菌和分枝杆菌培养。所有三次培养均为阴性。所有病例中的脓肿持续存在，需要进行物理切除和/或用透明质酸酶进行酶降解。只有在产品被取出后，症状才会消退。其中两名患者随后接受了其他透明质酸衍生的真皮填充剂治疗，未出现不良事件。
