Leth T, Jensen U, Fagt S, Andersen R
National Food Institute, DTU, Søborg, Denmark.
Food Addit Contam Part A Chem Anal Control Expo Risk Assess. 2008 Jun;25(6):662-8. doi: 10.1080/02652030701765749.
In 2005, 76 out of 177 analysed samples of non-alcoholic beverages were found to contain the intense sweeteners cyclamate, acesulfame-K, aspartame, and saccharin. The content of cyclamate did not exceed the now permitted maximum level in the European Union of 250 mg l(-1) in soft drinks. The estimated intake of the sweeteners was calculated using the Danish Dietary Survey based on 3098 persons aged 1-80 years. The estimated intake with 90th percentiles of 0.7, 0.8 and 0.2 mg kg(-1) body weight day(-1) for acesulfame-K, aspartame, and saccharin, respectively, was much lower than the acceptable daily intake values of 15, 40, 7, and 2.5 mg kg(-1) body weight day(-1) for acesulfame-K, aspartame, and saccharin, respectively, and on the same level as in the similar investigation from 1999. In contrast to the 1999 investigation, the 90th percentile of the estimated cyclamate intake in 1-3 year olds with 3.7 mg kg(-1) body weight day(-1) was in 2005 lower than the acceptable daily intake of 7 mg kg(-1) body weight day(-1). However, the 99th percentile for 1-3 year olds with 7.4 mg kg(-1) body weight day(-1) still exceeded the acceptable daily intake slightly. The 90th percentile for the whole population with 0.9 mg kg(-1) body weight day(-1) was halved compared with 1999. The reduction in the European Union of the maximum permitted level for cyclamate from 400 to 250 mg l(-1) has brought the intake of cyclamate in small children down to well below the acceptable daily intake value.
2005年，在177份分析的非酒精饮料样本中，发现76份含有人工合成甜味剂甜蜜素、安赛蜜、阿斯巴甜和糖精。甜蜜素含量未超过欧盟目前规定的软饮料中250毫克/升的最高限量。根据丹麦针对3098名年龄在1至80岁人群的饮食调查，计算了这些甜味剂的估计摄入量。安赛蜜、阿斯巴甜和糖精的估计摄入量第90百分位数分别为0.7、0.8和0.2毫克/千克体重/天，远低于各自的每日可接受摄入量，即安赛蜜15毫克/千克体重/天、阿斯巴甜40毫克/千克体重/天、糖精7毫克/千克体重/天，且与1999年的类似调查处于同一水平。与1999年的调查相比，2005年1至3岁儿童甜蜜素估计摄入量的第90百分位数为3.7毫克/千克体重/天，低于7毫克/千克体重/天的每日可接受摄入量。然而，1至3岁儿童甜蜜素估计摄入量的第99百分位数为7.4毫克/千克体重/天，仍略高于每日可接受摄入量。总体人群甜蜜素估计摄入量的第90百分位数为0.9毫克/千克体重/天，与1999年相比减半。欧盟将甜蜜素的最高允许限量从400毫克/升降至250毫克/升，使幼儿甜蜜素的摄入量降至远低于每日可接受摄入量的水平。
