Verger P, Khalfi N, Roy C, Blanchemanche S, Marette S, Roosen J
INRA-Met@risk.
Food Addit Contam Part A Chem Anal Control Expo Risk Assess. 2008 Jun;25(6):765-71. doi: 10.1080/02652030701816542.
A study of 401 fish-eating adults living in a coastal region of France was undertaken to establish exposure to dioxins/polychlorinated biphenyls and the intake of long-chain polyunsaturated fatty acids of the n-3 variety. Fish consumption was estimated using food frequency diaries and the dioxin/polychlorinated biphenyl data collected by the French control authorities was used to calculate dietary exposure. The results showed that for a group of adult subjects selected because of their consumption of fish, 60% achieved the nutritional recommendation for long-chain n-3 polyunsaturated fatty acids and 79% were exposed to total dioxins below the toxicological threshold of 14 pg kg(-1) body weight week(-1). Nevertheless, only 41% of these subjects had an optimal balance between the risk and benefit of eating fish, because 19% were meeting the nutritional recommendation but exceeding the toxicological threshold, whereas 38% were exposed below the toxicological threshold but failed to reach the recommended intake of long-chain n-3 polyunsaturated fatty acids. Similar results were found regarding the balance between long-chain n-3 polyunsaturated fatty acids and polychlorinated biphenyls even if a toxicological threshold was not established for these compounds. The results show that meeting the nutritional requirements of 0.5 mg day(-1) of long-chain n-3 polyunsaturated fatty acids is compatible with respect to toxicological thresholds, while an intake higher than 1.5 g day(-1) is likely to lead to a dietary exposure above the provisional tolerable weekly intake for dioxins.
对居住在法国沿海地区的401名食鱼成年人进行了一项研究，以确定其体内二噁英/多氯联苯的暴露情况以及n-3型长链多不饱和脂肪酸的摄入量。通过食物频率日记估算鱼类消费量，并使用法国监管当局收集的二噁英/多氯联苯数据来计算膳食暴露量。结果表明，对于一组因食用鱼类而被挑选出的成年受试者，60%达到了长链n-3多不饱和脂肪酸的营养推荐量，79%的受试者体内总二噁英暴露量低于14 pg kg⁻¹体重周⁻¹的毒理学阈值。然而，这些受试者中只有41%在食用鱼类的风险和益处之间达到了最佳平衡，因为19%的人达到了营养推荐量但超过了毒理学阈值，而38%的人暴露量低于毒理学阈值但未达到长链n-3多不饱和脂肪酸的推荐摄入量。即使未为这些化合物设定毒理学阈值，在长链n-3多不饱和脂肪酸和多氯联苯之间的平衡方面也发现了类似结果。结果表明，满足每天0.5 mg长链n-3多不饱和脂肪酸的营养需求在毒理学阈值方面是相容的，而摄入量高于每天1.5 g可能会导致二噁英的膳食暴露量超过暂定每周耐受摄入量。
