Sioen Isabelle, Van Camp John, Verdonck Frederik, Verbeke Wim, Vanhonacker Filiep, Willems Jan, De Henauw Stefaan
Department of Public Health, Ghent University, UZ-2 Blok A, De Pintelaan 185, B-9000 Ghent, Belgium.
Chemosphere. 2008 Apr;71(6):1056-66. doi: 10.1016/j.chemosphere.2007.11.025. Epub 2007 Dec 26.
Seafood represents a natural source of valuable nutrients (e.g., long chain omega-3 poly-unsaturated fatty acids (LC n-3 PUFAs), vitamin D, and iodine), but the favourable health perception is troubled by the presence of contaminants (e.g., PCBs, dioxin-like compounds, and (methyl) mercury (MeHg)). This dualism forms the basis for an important public health conflict. The objective of this study was to calculate and evaluate the simultaneous intake of multiple beneficial and harmful compounds (LC n-3 PUFAs, vitamin D, iodine, (Me)Hg, PCBs, and dioxin-like compounds) via seafood consumption in Belgium. A methodology and a software module were developed for executing probabilistic assessments of the simultaneous intake of multiple compounds leading to better insight in the problematic nature of food items involving both health benefits and risks. The simulations concerning seafood consumption in Belgium predicted that, as far as only seafood consumption is concerned, the considered populations do not reach a sufficiently high intake for the three nutrients considered (LC n-3 PUFAs, vitamin D, and iodine). Regarding the contaminants, (Me)Hg contamination of seafood on the Belgian market does not seem to be an issue of major toxicological concern. In contrast, for dioxin-like compounds the tolerable daily intake is reached by people with high seafood consumption.
海鲜是宝贵营养物质（如长链ω-3多不饱和脂肪酸（LC n-3 PUFAs）、维生素D和碘）的天然来源，但由于存在污染物（如多氯联苯、二噁英类化合物和（甲基）汞（MeHg）），其对健康的良好认知受到了困扰。这种二元性构成了一个重要的公共卫生冲突的基础。本研究的目的是计算和评估比利时人通过食用海鲜同时摄入多种有益和有害化合物（LC n-3 PUFAs、维生素D、碘、（甲基）汞、多氯联苯和二噁英类化合物）的情况。开发了一种方法和一个软件模块，用于对多种化合物的同时摄入进行概率评估，以便更好地了解涉及健康益处和风险的食品问题的本质。对比利时海鲜消费的模拟预测，就仅海鲜消费而言，所考虑的人群对所考虑的三种营养素（LC n-3 PUFAs、维生素D和碘）的摄入量未达到足够高的水平。关于污染物，比利时市场上海鲜的（甲基）汞污染似乎不是一个主要的毒理学问题。相比之下，对于二噁英类化合物，海鲜消费量高的人达到了每日可耐受摄入量。
