Stahlberg Henning, Walz Thomas
Molecular and Cellular Biology, College of Biological Sciences, University of California at Davis, Briggs Hall, 1 Shields Avenue, Davis, California 95616, USA.
ACS Chem Biol. 2008 May 16;3(5):268-81. doi: 10.1021/cb800037d.
The objective of molecular electron microscopy (EM) is to use electron microscopes to visualize the structure of biological molecules. This Review provides a brief overview of the methods used in molecular EM, their respective strengths and successes, and current developments that promise an even more exciting future for molecular EM in the structural investigation of proteins and macromolecular complexes, studied in isolation or in the context of cells and tissues.
分子电子显微镜（EM）的目标是利用电子显微镜来观察生物分子的结构。本综述简要概述了分子电子显微镜中使用的方法、它们各自的优势和成就，以及当前的发展情况，这些发展有望为分子电子显微镜在蛋白质和大分子复合物的结构研究中带来更加令人兴奋的未来，无论是对分离状态下的还是在细胞和组织环境中的蛋白质和大分子复合物进行研究。
