Wang Guan-Wu, Yuan Ting-Ting, Wu Xue-Liang
Hefei National Laboratory for Physical Sciences at Microscale, Joint Laboratory of Green Synthetic Chemistry, and Department of Chemistry, University of Science and Technology of China, Hefei, Anhui, PR China.
J Org Chem. 2008 Jun 20;73(12):4717-20. doi: 10.1021/jo8003088. Epub 2008 May 17.
Various anilides have been directly ortho-acetoxylated through a Pd(OAc)2-catalyzed C-H bond activation process. The amide group in anilides was found to functionalize as an elegant directing group to convert aromatic sp(2) C-H bonds into C-O bonds in high regioselectivity with acetic acid as the acetate source and K(2)S(2)O(8) as the oxidant.
通过钯（II）乙酸盐催化的C-H键活化过程，各种酰苯胺已被直接邻位乙酰氧基化。研究发现，酰苯胺中的酰胺基团可作为一种出色的导向基团，以乙酸作为乙酸根来源，过硫酸钾作为氧化剂，将芳香族sp(2) C-H键以高区域选择性转化为C-O键。
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