钯催化的酰胺与β-酮酯的氧化直接 C-H/C-H 交叉偶联。
Palladium-catalyzed oxidative direct C-H/C-H cross coupling of anilides with β-keto esters.
机构信息
State Key Laboratory for Chirosciences and Department of Applied Biology and Chemical Technology, The Hong Kong Polytechnic University, Hung Hom, Kowloon, Hong Kong.
出版信息
Chem Commun (Camb). 2013 Sep 25;49(74):8214-6. doi: 10.1039/c3cc44769c.
PMID:23925430
Abstract
A Pd(II)-catalyzed oxidative direct C(sp(2))-H/C(sp(3))-H cross coupling of anilides with α-dicarbonyl compounds with Mn(OAc)3·2H2O as the oxidant is reported and this protocol provides facile access to α-aryl malonates and β-keto esters in good yields and regioselectivity.
摘要
报道了一种 Pd(II)催化的芳酰胺与α-二羰基化合物的氧化直接 C(sp(2))-H/C(sp(3))-H 交叉偶联反应，该反应以 Mn(OAc)3·2H2O 为氧化剂，为合成α-芳基丙二酸酯和β-酮酯提供了一种简便、高产率和区域选择性的方法。
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