State Key Laboratory for Chirosciences and Department of Applied Biology and Chemical Technology, The Hong Kong Polytechnic University, Hung Hom, Kowloon, Hong Kong.
Chem Commun (Camb). 2013 Sep 25;49(74):8214-6. doi: 10.1039/c3cc44769c.
A Pd(II)-catalyzed oxidative direct C(sp(2))-H/C(sp(3))-H cross coupling of anilides with α-dicarbonyl compounds with Mn(OAc)3·2H2O as the oxidant is reported and this protocol provides facile access to α-aryl malonates and β-keto esters in good yields and regioselectivity.
报道了一种 Pd(II)催化的芳酰胺与α-二羰基化合物的氧化直接 C(sp(2))-H/C(sp(3))-H 交叉偶联反应，该反应以 Mn(OAc)3·2H2O 为氧化剂，为合成α-芳基丙二酸酯和β-酮酯提供了一种简便、高产率和区域选择性的方法。
