钯催化的 N-甲氧基苯甲酰胺的烷氧基化反应通过直接 sp2 C-H 键活化。
Palladium-catalyzed alkoxylation of N-methoxybenzamides via direct sp2 C-H bond activation.
机构信息
CAS Key Laboratory of Soft Matter Chemistry, and Department of Chemistry, University of Science and Technology of China, Hefei, Anhui 230026, People's Republic of China.
出版信息
J Org Chem. 2010 Jan 15;75(2):476-9. doi: 10.1021/jo902139b.
PMID:20000348
Abstract
The palladium-catalyzed ortho-alkoxylation of N-methoxybenzamides has been demonstrated. With the CONHOMe group as a directing group, the aromatic C-H bond can be functionalized efficiently to generate ortho-alkoxylated derivatives in moderate to good yields.
摘要
钯催化的 N-甲氧基苯甲酰胺的邻位烷氧基化反应已经得到了证明。以 CONHOMe 基团作为导向基团，可以有效地官能化芳环的 C-H 键，以中等至良好的收率生成邻位烷氧基化衍生物。
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