Xu Duan, Cunningham Charles H, Chen Albert P, Li Yan, Kelley Douglas A C, Mukherjee Pratik, Pauly John M, Nelson Sarah J, Vigneron Daniel B
Joint UCSF/UC Berkeley Graduate Group in Bioengineering, University of California, San Francisco and Berkeley, CA 94143, USA.
Magn Reson Imaging. 2008 Nov;26(9):1201-6. doi: 10.1016/j.mri.2008.03.006. Epub 2008 May 16.
Ultra-high-field 7 T magnetic resonance (MR) scanners offer the potential for greatly improved MR spectroscopic imaging due to increased sensitivity and spectral resolution. Prior 7 T human single-voxel MR Spectroscopy (MRS) studies have shown significant increases in signal-to-noise ratio (SNR) and spectral resolution as compared to lower magnetic fields but have not demonstrated the increase in spatial resolution and multivoxel coverage possible with 7 T MR spectroscopic imaging. The goal of this study was to develop specialized radiofrequency (RF) pulses and sequences for three-dimensional (3D) MR spectroscopic imaging (MRSI) at 7 T to address the challenges of increased chemical shift misregistration, B1 power limitations, and increased spectral bandwidth. The new 7 T MRSI sequence was tested in volunteer studies and demonstrated the feasibility of obtaining high-SNR phased-array 3D MRSI from the human brain.
超高场7T磁共振（MR）扫描仪由于灵敏度和光谱分辨率的提高，为大幅改进磁共振波谱成像提供了潜力。先前的7T人体单体素磁共振波谱（MRS）研究表明，与较低磁场相比，信噪比（SNR）和光谱分辨率有显著提高，但尚未证明7T磁共振波谱成像在空间分辨率和多体素覆盖方面的提高。本研究的目的是开发用于7T三维（3D）磁共振波谱成像（MRSI）的专用射频（RF）脉冲和序列，以应对化学位移配准错误增加、B1功率限制和光谱带宽增加等挑战。新的7T MRSI序列在志愿者研究中进行了测试，并证明了从人脑获得高SNR相控阵3D MRSI的可行性。
