在乳腺肿瘤病毒转基因小鼠中，对携带Vβ14的T细胞进行克隆清除。
Clonal deletion of V beta 14-bearing T cells in mice transgenic for mammary tumour virus.
作者信息
Acha-Orbea H, Shakhov A N, Scarpellino L, Kolb E, Müller V, Vessaz-Shaw A, Fuchs R, Blöchlinger K, Rollini P, Billotte J
机构信息
Ludwig Institute for Cancer Research, Lausanne Branch, Epalinges, Switzerland.
出版信息
Nature. 1991 Mar 21;350(6315):207-11. doi: 10.1038/350207a0.
Autoreactive T lymphocytes are clonally deleted during maturation in the thymus. Deletion of T cells expressing particular receptor V beta elements is controlled by poorly defined autosomal dominant genes. A gene has now been identified by expression of transgenes in mice which causes deletion of V beta 14+ T cells. The gene lies in the open reading frame of the long terminal repeat of the mouse mammary tumour virus.
自身反应性T淋巴细胞在胸腺成熟过程中发生克隆性缺失。表达特定受体Vβ元件的T细胞的缺失由定义不清的常染色体显性基因控制。现在通过在小鼠中表达转基因鉴定出了一个基因，该基因可导致Vβ14 + T细胞缺失。该基因位于小鼠乳腺肿瘤病毒长末端重复序列的开放阅读框中。
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