通过用游离合成肽在体内引发病毒特异性细胞毒性T淋巴细胞来预防致死性仙台病毒感染。
Protection against lethal Sendai virus infection by in vivo priming of virus-specific cytotoxic T lymphocytes with a free synthetic peptide.
作者信息
Kast W M, Roux L, Curren J, Blom H J, Voordouw A C, Meloen R H, Kolakofsky D, Melief C J
机构信息
Division of Immunology, The Netherlands Cancer Institute, Amsterdam.
出版信息
Proc Natl Acad Sci U S A. 1991 Mar 15;88(6):2283-7. doi: 10.1073/pnas.88.6.2283.
Abstract
The only peptide of Sendai virus that is recognized by cytotoxic T lymphocytes (CTL) in B6 mice was found with (i) the use of recombinant vaccinia virus constructs containing separate genes of Sendai virus and (ii) a set of overlapping peptides completely spanning the identified nucleoprotein (NP) gene product. This immunodominant NP peptide is recognized by Sendai virus-specific CTL that are known to have therapeutic effects in vivo. By subcutaneous immunization, this peptide induced Sendai virus and NP peptide-specific CTL memory responses in vivo. Most importantly, mice that had been immunized with this peptide were protected against a lethal virus dose, indicating that viral peptides can be used as antiviral T-cell vaccines. The induction of T-cell memory by free peptide immunization potentially has wide applicability in biology and medicine, including protection against infectious disease.
摘要
在B6小鼠中，通过以下两种方法发现了仙台病毒唯一能被细胞毒性T淋巴细胞（CTL）识别的肽：（i）使用含有仙台病毒单独基因的重组痘苗病毒构建体；（ii）一组完全覆盖已鉴定核蛋白（NP）基因产物的重叠肽。这种免疫显性NP肽可被已知在体内具有治疗作用的仙台病毒特异性CTL识别。通过皮下免疫，该肽在体内诱导了仙台病毒和NP肽特异性CTL记忆反应。最重要的是，用该肽免疫的小鼠对致死剂量的病毒具有抵抗力，这表明病毒肽可作为抗病毒T细胞疫苗。游离肽免疫诱导T细胞记忆在生物学和医学中可能具有广泛的适用性，包括预防传染病。
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