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鼻疽伯克霍尔德菌的BmaR3-BmaI3群体感应系统产生并响应N-3-羟基辛酰高丝氨酸内酯。

The Burkholderia mallei BmaR3-BmaI3 quorum-sensing system produces and responds to N-3-hydroxy-octanoyl homoserine lactone.

作者信息

Duerkop Breck A, Herman Jake P, Ulrich Ricky L, Churchill Mair E A, Greenberg E Peter

机构信息

Department of Microbiology, University of Washington School of Medicine, Seattle, Washington 98195-7242, USA.

出版信息

J Bacteriol. 2008 Jul;190(14):5137-41. doi: 10.1128/JB.00246-08. Epub 2008 May 16.

DOI:10.1128/JB.00246-08
PMID:18487338
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC2447019/
Abstract

Burkholderia mallei has two acyl-homoserine lactone (acyl-HSL) signal generator-receptor pairs and two additional signal receptors, all of which contribute to virulence. We show that B. mallei produces N-3-hydroxy-octanoyl HSL (3OHC8-HSL) but a bmaI3 mutant does not. Recombinant Escherichia coli expressing BmaI3 produces hydroxylated acyl-HSLs, with 3OHC8-HSL being the most abundant compound. In recombinant E. coli, BmaR3 responds to 3OHC8-HSL but not to other acyl-HSLs. These data indicate that the signal for BmaR3-BmaI3 quorum sensing is 3OHC8-HSL.

摘要

鼻疽伯克霍尔德菌有两对酰基高丝氨酸内酯（acyl-HSL）信号生成-受体对以及另外两个信号受体，所有这些都与毒力有关。我们发现鼻疽伯克霍尔德菌产生N-3-羟基辛酰高丝氨酸内酯（3OHC8-HSL），但bmaI3突变体不产生。表达BmaI3的重组大肠杆菌产生羟基化的酰基高丝氨酸内酯，其中3OHC8-HSL是最丰富的化合物。在重组大肠杆菌中，BmaR3对3OHC8-HSL有反应，但对其他酰基高丝氨酸内酯没有反应。这些数据表明，BmaR3-BmaI3群体感应的信号是3OHC8-HSL。

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The Burkholderia mallei BmaR3-BmaI3 quorum-sensing system produces and responds to N-3-hydroxy-octanoyl homoserine lactone.鼻疽伯克霍尔德菌的BmaR3-BmaI3群体感应系统产生并响应N-3-羟基辛酰高丝氨酸内酯。
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本文引用的文献

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Glanders: off to the races with Burkholderia mallei.鼻疽：与鼻疽伯克霍尔德菌展开竞赛。
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N-(3-hydroxyhexanoyl)-l-homoserine lactone is the biologically relevant quormone that regulates the phz operon of Pseudomonas chlororaphis strain 30-84.N-(3-羟基己酰基)-L-高丝氨酸内酯是调节绿针假单胞菌30-84菌株phz操纵子的具有生物学相关性的群体感应信号分子。
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Octanoyl-homoserine lactone is the cognate signal for Burkholderia mallei BmaR1-BmaI1 quorum sensing.辛酰基高丝氨酸内酯是鼻疽伯克霍尔德菌BmaR1 - BmaI1群体感应的同源信号。
J Bacteriol. 2007 Jul;189(14):5034-40. doi: 10.1128/JB.00317-07. Epub 2007 May 11.
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Quorum sensing regulates dpsA and the oxidative stress response in Burkholderia pseudomallei.群体感应调控类鼻疽伯克霍尔德菌中的dpsA和氧化应激反应。
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Studies on Certain Biological Characteristics of Malleomyces mallei and Malleomyces pseudomallei: II. Virulence and Infectivity for Animals.鼻疽芽生菌和类鼻疽芽生菌某些生物学特性的研究：II. 对动物的毒力和传染性
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Specificity of acyl-homoserine lactone synthases examined by mass spectrometry.通过质谱法检测酰基高丝氨酸内酯合酶的特异性。
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J Bacteriol. 2005 Sep;187(18):6517-27. doi: 10.1128/JB.187.18.6517-6527.2005.
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