作为天然产物的来源。
as a Source of Natural Products.
机构信息
Department of Medicinal Chemistry and Pharmacognosy and Center for Biomolecular Sciences, College of Pharmacy , University of Illinois at Chicago , Chicago , Illinois 60607 , United States.
出版信息
J Nat Prod. 2019 Jul 26;82(7):2018-2037. doi: 10.1021/acs.jnatprod.8b01068. Epub 2019 Jul 11.
bacteria are multifaceted organisms that are ecologically and metabolically diverse. The genus has gained prominence because it includes human pathogens; however, many strains are nonpathogenic and have desirable characteristics such as beneficial plant associations and degradation of pollutants. The diversity of the genus is reflected within the large genomes that feature multiple replicons. genomes encode a plethora of natural products with potential therapeutic relevance and biotechnological applications. This review highlights as an emerging source of natural products. An overview of the taxonomy of the genus, which is currently being revised, is provided. We then present a curated compilation of natural products isolated from sensu lato and analyze their characteristics in terms of biosynthetic class, discovery method, and bioactivity. Finally, we describe and discuss genome characteristics and highlight the biosynthesis of a select number of natural products that are encoded in unusual biosynthetic gene clusters. The availability of >1000 genomes in public databases provides an opportunity to realize the genetic potential of this underexplored taxon for natural product discovery.
细菌是具有多面性的生物体，在生态和代谢方面具有多样性。该属之所以受到关注，是因为它包含了人类病原体；然而，许多菌株是非致病性的，具有理想的特性，如与植物有益的共生关系和对污染物的降解。该属的多样性反映在具有多个复制子的大型基因组中。基因组编码了大量具有潜在治疗相关性和生物技术应用的天然产物。本综述强调了 作为天然产物的新兴来源。提供了对该属分类群的概述，目前正在修订中。然后，我们展示了从 广义 sensu 中分离出的天然产物的精心编纂，并根据生物合成类别、发现方法和生物活性对其进行了分析。最后，我们描述并讨论了基因组特征，并强调了在不寻常的生物合成基因簇中编码的选定天然产物的生物合成。在公共数据库中提供了 >1000 个基因组，为实现这个未充分探索的分类群在天然产物发现方面的遗传潜力提供了机会。
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