Shah Baiju R, Retnakaran Ravi, Booth Gillian L
Department of Medicine, University of Toronto, Toronto, Ontario, Canada.
Diabetes Care. 2008 Aug;31(8):1668-9. doi: 10.2337/dc08-0706. Epub 2008 May 16.
To determine whether women with gestational diabetes mellitus (GDM) have an increased risk of cardiovascular disease (CVD) following pregnancy.
All women aged 20-49 years with live births between April 1994 and March 1997 in Ontario, Canada, were identified. Women with GDM were matched with 10 women without GDM and were followed for CVD.
The matched cohorts included 8,191 women with GDM and 81,262 women without GDM. Mean age at entry was 31 years, and median follow-up was 11.5 years. The hazard ratio for CVD events was 1.71 (95% CI 1.08-2.69). After adjustment for subsequent type 2 diabetes, the hazard ratio was attenuated (1.13 [95% CI 0.67-1.89]).
Young women with GDM had a substantially increased risk for CVD compared with women without GDM. Much of this increased risk was attributable to subsequent development of type 2 diabetes.
确定妊娠糖尿病（GDM）女性在产后发生心血管疾病（CVD）的风险是否增加。
确定了1994年4月至1997年3月在加拿大安大略省所有年龄在20 - 49岁之间有活产记录的女性。患有GDM的女性与10名无GDM的女性进行匹配，并对其进行CVD随访。
匹配队列包括8191名患有GDM的女性和81262名无GDM的女性。入组时的平均年龄为31岁，中位随访时间为11.5年。CVD事件的风险比为1.71（95%可信区间1.08 - 2.69）。在对后续的2型糖尿病进行校正后，风险比有所降低（1.13 [95%可信区间0.67 - 1.89]）。
与无GDM的女性相比，患有GDM的年轻女性发生CVD的风险大幅增加。这种风险增加很大程度上归因于后续2型糖尿病的发生。
